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New treatment option for Major Depressive Disorder
Official title Maintenance rTMS for Depression (Maitr-De)
ClinicalTrials.gov ID: NCT06938841
What this study is testing
- What it's testing
- Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a maintenance treatment. This prospective study seeks to investigate the efficacy of maintenance rTMS in individuals with TRD who have previously responded to an acute course of rTMS.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- They met criteria for a DSM-5 diagnosis of a Major Depressive Episode (MDE) during the index episode of depression for which they have received an...
- Meet criteria for either response or remission from their initial depressive illness. The MINI assessment timeline will be adjusted to allow scoring...
- Their initial rTMS treatment course must have consisted of at least 15 rTMS treatment sessions.
- People between the ages of 18 and 80 at the time of screening. A written statement from the referring physician will be required to confirm that the...
- Able to read, understand, and provide written, dated informed consent prior to screening. Proficiency in English sufficient to complete...
You likely can't join if
- 1\. Pregnancy 2. History of or current psychotic disorder or depression with psychotic features 3. Severe borderline personality disorder based on...
- 8\. Recent (during the current depressive episode) or concurrent use of rapid-acting antidepressant agent (i.e., ketamine or a course of ECT) in the...
See the full eligibility criteria
- They met criteria for a DSM-5 diagnosis of a Major Depressive Episode (MDE) during the index episode of depression for which they have received an acute rTMS treatment course.
- Meet criteria for either response or remission from their initial depressive illness. The MINI assessment timeline will be adjusted to allow scoring of illness symptoms prior to rTMS response. Response to acute course...
- Their initial rTMS treatment course must have consisted of at least 15 rTMS treatment sessions.
- People between the ages of 18 and 80 at the time of screening. A written statement from the referring physician will be required to confirm that the participant demonstrates the capacity to consent.
- Able to read, understand, and provide written, dated informed consent prior to screening. Proficiency in English sufficient to complete questionnaires / follow instructions during TMS-EEG assessments and iTBS...
- In good general health, as evidenced by medical history.
- Agreement to adhere to Lifestyle Considerations throughout study duration.
- If a person of child-bearing potential is: must take a pregnancy test at the screening visit, with results confirmed as negative by study staff
- 1\. Pregnancy 2. History of or current psychotic disorder or depression with psychotic features 3. Severe borderline personality disorder based on clinical assessment. 4. Diagnosis of Intellectual Disability or Autism...
- 8\. Recent (during the current depressive episode) or concurrent use of rapid-acting antidepressant agent (i.e., ketamine or a course of ECT) in the last 30 days 9. History of significant neurologic disease, including...
The study team makes the final eligibility decision.
Where it's taking place
- San Diego, California, United States
- New York, New York, United States
- Canberra, Australian Capital Territory, Australia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include San Diego, California, United States; New York, New York, United States; Canberra, Australian Capital Territory, Australia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.