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New treatment option for Postoperative Pain
Official title Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management
ClinicalTrials.gov ID: NCT06937853
What this study is testing
What is Ibuprofen 600 mg?
Ibuprofen 600 mg is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for postoperative pain.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to evaluate the influence of genetic polymorphisms on the effectiveness of preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain following endodontic treatment. Participants will receive standard preoperative NSAIDs before undergoing root canal therapy, and their pain responses will be assessed.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Patients aged between 18 and 65 years
- Vital mandibular molar teeth diagnosed with symptomatic apical periodontitis
- ASA physical status classification I or II
- Preoperative VAS pain score greater than 50
- No known genetic disorders (e.g., Down syndrome, congenital insensitivity to pain)
You likely can't join if
- Patients classified as ASA III or higher
- Pregnant women or those suspected of being pregnant
- Presence of root canal curvature greater than 25° (Schilder classification)
- Patients with generalized periodontitis
- Presence of periodontal pockets deeper than 3 mm in the affected tooth
- History of systemic disease or known allergies
See the full eligibility criteria
- Patients aged between 18 and 65 years
- Vital mandibular molar teeth diagnosed with symptomatic apical periodontitis
- ASA physical status classification I or II
- Preoperative VAS pain score greater than 50
- No known genetic disorders (e.g., Down syndrome, congenital insensitivity to pain)
- Patients classified as ASA III or higher
- Pregnant women or those suspected of being pregnant
- Presence of root canal curvature greater than 25° (Schilder classification)
- Patients with generalized periodontitis
- Presence of periodontal pockets deeper than 3 mm in the affected tooth
- History of systemic disease or known allergies
- Patients with diagnosed psychiatric or psychological disorders
- Presence of swelling, sinus tract, or preoperative tenderness on palpation
- Patients with bruxism
- Presence of resorption in the affected tooth
- Use of analgesic or anti-inflammatory drugs within 12 hours prior to the procedure
- Teeth with root fractures, ankylosis, or pathological mobility
The study team makes the final eligibility decision.
Where it's taking place
- Erzurum, Erzurum, Turkey (Türkiye)
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Erzurum, Erzurum, Turkey (Türkiye). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.