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Tests treatment safety and results for Alzheimer Disease
Official title A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
ClinicalTrials.gov ID: NCT06937229
What this study is testing
What is KarXT?
KarXT is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for alzheimer disease.
Also referred to as Xanomeline and Trospium Chloride capsule, BMS-986510.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to evaluate the long-term efficacy and safety of combined formulation of xanomeline tartrate/trospium chloride in an immediate release (IR) capsule (KarXT) and xanomeline enteric capsules (KarX-EC) in participants with agitation associated with Alzheimer's Disease who completed the parent studies CN012-0023 or CN012-0024.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 55 to 90
You may be able to join if
- Participants must have completed study CN012-0023 or CN012-0024 per protocol.
- Participants must have an identified caregiver who has sufficient contact (approximately 8 hours over a week).
You likely can't join if
- Participants must not have clinically significant cardiovascular (eg, untreated or unstable hypertension, clinically significant tachycardia)...
- Other protocol-defined Inclusion/Exclusion criteria apply.
The study team makes the final eligibility decision.
Where it's taking place
- Chandler, Arizona, United States
- Scottsdale, Arizona, United States
- Anaheim, California, United States
- Canoga Park, California, United States
- La Jolla, California, United States
- Long Beach, California, United States
- Orange, California, United States
- Pasadena, California, United States
- Pomona, California, United States
- Torrance, California, United States
- Walnut Creek, California, United States
- Bonita Springs, Florida, United States
- Hialeah, Florida, United States
- Miami, Florida, United States
- Orlando, Florida, United States
- Port Orange, Florida, United States
- Tampa, Florida, United States
- Virginia Gardens, Florida, United States
- Atlanta, Georgia, United States
- Gaithersburg, Maryland, United States
+ 187 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 55 years to 90 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Chandler, Arizona, United States; Scottsdale, Arizona, United States; Anaheim, California, United States; Canoga Park, California, United States; La Jolla, California, United States; Long Beach, California, United States and 201 more location(s). Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.