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New treatment option for Richter's Transformation
Official title ONO-4538 Study in Patients With Richter's Transformation
ClinicalTrials.gov ID: NCT06936943
What this study is testing
What is ONO-4538?
ONO-4538 is an investigational medicine, being studied as a potential treatment for richter's transformation.
Also referred to as Nivolumab, Opdivo.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Investigate the efficacy and safety of ONO-4538 in patients with Richter's transformation
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Histological diagnosis of diffuse large B-cell lymphoma (DLBCL)-type or Hodgkin lymphoma(HL)-type Richter's transformation with a history of chronic...
- In the case of DLBCL-type Richter's transformation, refractory, intolerant or ineligible for treatment of DLBCL
- Patients with measurable disease
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Expected to survive for 90 days or more
You likely can't join if
- Serious complications
- Active multiple cancers
- Active central nervous system (CNS) disease
- History of allogeneic hematopoietic stem cell transplantation
The study team makes the final eligibility decision.
Where it's taking place
- Nagoya, Aichi-ken, Japan
- Fukuoka, Fukuoka, Japan
- Hiroshima, Hiroshima, Japan
- Sapporo, Hokkaido, Japan
- Kyoto, Kyoto, Japan
- Sendai, Miyagi, Japan
- Niigata, Niigata, Japan
- Ōsaka-sayama, Osaka, Japan
- Bunkyō-Ku, Tokyo, Japan
- Chuo Ku, Tokyo, Japan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nagoya, Aichi-ken, Japan; Fukuoka, Fukuoka, Japan; Hiroshima, Hiroshima, Japan; Sapporo, Hokkaido, Japan; Kyoto, Kyoto, Japan; Sendai, Miyagi, Japan and 4 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.