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New treatment option for Acute Hypoxemic Respiratory Failure
Official title EIT-Guided Ventilator Settings in AHRF
ClinicalTrials.gov ID: NCT06936618
What this study is testing
- What it's testing
- This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and non-ARDS conditions. Mechanical power, a key factor associated with ventilator-induced lung injury (VILI), will be measured before and after EIT-guided PEEP titration.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years
- Diagnosed with acute hypoxemic respiratory failure within 48 hours
- Expected to require invasive mechanical ventilation ≥ 48 hours
- On mechanical ventilation within 24 hours
- Deep sedation and neuromuscular blockade
You likely can't join if
- Pregnancy
- Body mass index (BMI) \> 40 kg/m2
- Contraindications to using electrical impedance tomography, including
- Presence of a pacemaker or automatic implantable cardioverter-defibrillator (AICD)
- Inability to place the belt due to presence of surgical wounds dressing, thoracic or spinal cord trauma, recent thoracic surgery, etc.
- High risk for PEEP titration
See the full eligibility criteria
- Age ≥ 18 years
- Diagnosed with acute hypoxemic respiratory failure within 48 hours
- Expected to require invasive mechanical ventilation ≥ 48 hours
- On mechanical ventilation within 24 hours
- Deep sedation and neuromuscular blockade
- Pregnancy
- Body mass index (BMI) \> 40 kg/m2
- Contraindications to using electrical impedance tomography, including
- Presence of a pacemaker or automatic implantable cardioverter-defibrillator (AICD)
- Inability to place the belt due to presence of surgical wounds dressing, thoracic or spinal cord trauma, recent thoracic surgery, etc.
- High risk for PEEP titration
- Hemodynamic instability defined as mean arterial pressure \< 65 mmHg despite optimization of fluid status and/or use of vasopressors
- Unstable cardiac arrhythmias
- Presence of lung bullae greater than 2 cm in diameter, identified on chest X-ray
- Presence of pneumothorax or pneumomediastinum
- Right-sided heart failure or severe pulmonary hypertension
- Neurologic conditions associated with a risk of intracranial hypertension
- Use of extracorporeal membrane oxygenation (ECMO)
- Severe chronic respiratory disease, defined as follows: requiring home oxygen therapy, or previous lung function showing (FEV1 less than 20 ml/kg PBW, or FEV1/FVC less than 50% predicted value), or chronic hypercapnia...
- Decision to withhold life-sustaining treatment or palliative care.
- Moribund status with an expected survival of less than 24 hours.
- Refusal to provide informed consent
The study team makes the final eligibility decision.
Where it's taking place
- Bangkok, Thailand
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bangkok, Thailand. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.