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Compares treatment options for Colorectal Carcinoma
Official title Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery
ClinicalTrials.gov ID: NCT06935708
What this study is testing
What is Intrathecal Morphine?
Intrathecal Morphine is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for colorectal carcinoma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Effective pain management after abdominal surgery is essential for recovery. This study compares two pain relief methods-intrathecal morphine (a single spinal injection) and continuous epidural analgesia-for patients undergoing open colorectal cancer surgery.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Male or female patients with colorectal carcinoma undergoing laparoscopic abdominal surgery aged 18-80 years, ASA classification I-III, Body Mass...
You likely can't join if
- abnormal coagulation function, defined as prothrombin time or activated partial prothrombin time above standard laboratory values or an international...
- thrombocytopenia, defined as a platelet count \<80×10 9 L-1,
- pre-existing skin infection at the neuraxial anesthesia puncture site,
- pre-existing neurologic deficit, including peripheral neuropathy,
- patients with dementia or other medical condition that includes communication difficulties,
- patients with bradycardia (pulse \<50/min) or with conduction block (2nd or 3rd degree)
See the full eligibility criteria
- Male or female patients with colorectal carcinoma undergoing laparoscopic abdominal surgery aged 18-80 years, ASA classification I-III, Body Mass Index (BMI) 15-35 kg/m2.
- abnormal coagulation function, defined as prothrombin time or activated partial prothrombin time above standard laboratory values or an international normalised ratio (INR) ≥1.4; or receiving ongoing therapeutic...
- thrombocytopenia, defined as a platelet count \<80×10 9 L-1,
- pre-existing skin infection at the neuraxial anesthesia puncture site,
- pre-existing neurologic deficit, including peripheral neuropathy,
- patients with dementia or other medical condition that includes communication difficulties,
- patients with bradycardia (pulse \<50/min) or with conduction block (2nd or 3rd degree)
- history of opioid abuse,
- allergies to any of the drugs used in the study. Additionally, patients converted from laparoscopy to laparotomy due to technical surgical issues, patients with postoperative surgical complications (need for revision)...
The study team makes the final eligibility decision.
Where it's taking place
- Split, Croatia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Split, Croatia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.