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Tests treatment safety and results for Herpes Zoster (HZ)
Official title A Study to Evaluate the Safety of Recombinant Herpes Zoster Vaccine for Healthy Individuals
ClinicalTrials.gov ID: NCT06932523
What this study is testing
What is Recombinant herpes zoster vaccine with low-dose adjuvant?
Recombinant herpes zoster vaccine with low-dose adjuvant is an investigational medicine, given as an injection into a muscle, being studied as a potential treatment for herpes zoster (hz).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this clinical study is to evaluate the safety and immunogenicity of receiving two doses of recombinant herpes zoster vaccine (CHO cells) (RHZV) in healthy individuals aged 40 years and above. This study will be conducted in 2 substudies: Substudy A (Phase I) and Substudy B (Phase Ⅱ).
- Phase 2: a mid-size study of how well it works
- Time commitment: about 2 years
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 and older. Healthy volunteers may be eligible.
You may be able to join if
- Age ≥ 40 years old on the day of enrollment, gender not limited.
- Can provide legal proof of identity.
- Be able to understand the experimental procedure and sign a written informed consent form, expressing agreement to participate in the experiment.
- Be able to participate in all planned follow-up visits and comply with all trial procedures.
- On the day of enrollment, the body temperature was less than 37.3 ℃ (axillary temperature).
You likely can't join if
- Individuals with a history of herpes zoster in the past.
- Individuals with a history of vaccination against chickenpox or shingles.
- Individuals who have had close contact with patients with chickenpox or shingles in the past 2 years.
- Women of childbearing age who have a positive urine pregnancy test, are breastfeeding, pregnant, or plan to become pregnant within 6 months after the...
- Individuals who are allergic to any component of the vaccine or have a history of other severe allergies.
- Use immunoglobulin and/or any blood products within 3 months prior to administering the trial vaccine, or plan to use them during the trial period.
See the full eligibility criteria
- Age ≥ 40 years old on the day of enrollment, gender not limited.
- Can provide legal proof of identity.
- Be able to understand the experimental procedure and sign a written informed consent form, expressing agreement to participate in the experiment.
- Be able to participate in all planned follow-up visits and comply with all trial procedures.
- On the day of enrollment, the body temperature was less than 37.3 ℃ (axillary temperature).
- Chronic disease patients need to be in a stable period of chronic disease.
- Female and male participants of childbearing age agreed to adopt strict and effective contraceptive measures from the start of the trial to 6 months after full exemption.
- Individuals with a history of herpes zoster in the past.
- Individuals with a history of vaccination against chickenpox or shingles.
- Individuals who have had close contact with patients with chickenpox or shingles in the past 2 years.
- Women of childbearing age who have a positive urine pregnancy test, are breastfeeding, pregnant, or plan to become pregnant within 6 months after the start of the test and the full exemption period.
- Individuals who are allergic to any component of the vaccine or have a history of other severe allergies.
- Use immunoglobulin and/or any blood products within 3 months prior to administering the trial vaccine, or plan to use them during the trial period.
- Have taken antipyretic, analgesic, or anti allergic drugs within 72 hours prior to receiving the experimental vaccine.
- Any experimental or unregistered product (drug, vaccine, biological product or device) other than the experimental vaccine has been used within one month prior to vaccination, or is planned to be used during the trial...
- Administer non live vaccines within 7 days prior to administering the experimental vaccine or live vaccines within 14 days prior to administering the experimental vaccine.
- Suffering from a serious illness that prevents the completion of the entire experiment.
- Received immunosuppressive therapy or other immunomodulatory drugs, monoclonal antibodies, thymosin, interferon, etc. within 6 months prior to vaccination with the experimental vaccine, or planned to receive such...
- Chemotherapy, radiotherapy, and organ and bone marrow transplantation related treatments for cancer or other diseases.
- Diseases or medical measures that lead to immune dysfunction
- Individuals currently suffering from serious infectious diseases such as active tuberculosis and active viral hepatitis.
- Moderate or severe acute illness/infection, or febrile illness within 72 hours prior to vaccination.
- Known to have a history of thrombocytopenia, any coagulation dysfunction, or being treated with anticoagulants.
- Suffering from serious cardiovascular disease, pulmonary edema, serious liver and kidney disease, and diabetes that cannot be controlled by drugs.
- Previous history of mental and neurological disorders or family history of mental illness.
- Currently suffering from various severe infectious, suppurative, and allergic skin diseases.
- Plan to move before the end of the trial or leave the local area for a long time during the scheduled trial visit.
- (Phase I ) Abnormal blood routine, blood biochemistry, coagulation, and urine routine indicators before vaccination (excluding those judged by doctors to have no clinical significance).
- Any situation that the researcher believes may affect the evaluation of the experiment.
The study team makes the final eligibility decision.
Where it's taking place
- Wuhan, Hubei, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 2 years per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Wuhan, Hubei, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.