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New treatment option for Autonomic Function
Official title Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
ClinicalTrials.gov ID: NCT06912048
What this study is testing
- What it's testing
- The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagonist atropine.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Age: at least 18
- BMI: 20 - 24.9 kg/m2 (for the healthy groups) or more than 28 kg/m2 (for the overweight groups)
- For women: Hormonal contraception with a single-phase preparation (e.g. Nuvaring)
- Understanding and voluntarily signing an informed consent form prior to study-related examinations
You likely can't join if
- Drug and/or alcohol abuse
- smoking
- Taking medication that affects blood sugar or addresses the central and/or autonomic nervous system (e.g. anti-epileptic drugs, beta blockers...
- Pre-existing cardiac conditions
- Neurological pre-existing conditions
- Known cardiac arrhythmia
See the full eligibility criteria
- Age: at least 18
- BMI: 20 - 24.9 kg/m2 (for the healthy groups) or more than 28 kg/m2 (for the overweight groups)
- For women: Hormonal contraception with a single-phase preparation (e.g. Nuvaring)
- Understanding and voluntarily signing an informed consent form prior to study-related examinations
- Drug and/or alcohol abuse
- smoking
- Taking medication that affects blood sugar or addresses the central and/or autonomic nervous system (e.g. anti-epileptic drugs, beta blockers, dopamine agonists, antidepressants). Taking antihistamines.
- Pre-existing cardiac conditions
- Neurological pre-existing conditions
- Known cardiac arrhythmia
- Known allergies to ingredients, e.g. paracetamol and atropine
- Known narrow-angle glaucoma
- Known hyperthyroidism
- Known diseases of the urinary tract or prostate
- Pregnancy or breastfeeding
- At screening: Hb \< 12 g/dl for women and Hb \< 14 g/dl for men
- No consent to be informed about incidentally discovered pathological findings
- Any (clinical) condition which, in the opinion of the physician, could jeopardize the safety of the
- or would jeopardize the scientific success.
- Liver dysfunction
- Renal insufficiency
The study team makes the final eligibility decision.
Where it's taking place
- Ulm, Germany
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Ulm, Germany. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.