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New treatment option for Cannabis Use Disorder, Severe
Official title Cannabis and Processing Emotions Study
ClinicalTrials.gov ID: NCT06907979
What this study is testing
- What it's testing
- The goal of this study is to test a causal neural mechanism of cannabis use-related problem recognition in individuals with severe cannabis use disorder using a non-invasive form of neuromodulation called transcranial magnetic stimulation (TMS). The main question it aims to answer is: -Does manipulating neural activity in the medial orbitofrontal cortex of the brain affect cannabis use-related problem recognition?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 50
You may be able to join if
- Meets criteria for current, severe Cannabis Use Disorder (CUD), as assessed by the Structured Clinical Interview (SCID) for the Diagnostic and...
- Reports engagement in cannabis use at least four days per week, on average, over the past year
- Provide a urine sample positive for tetrahydrocannabinol (THC)
- Able to read and write in English
- Has used cannabis at least 20 days in the past month
You likely can't join if
- Other non-cannabis illicit substance use more than once per month, on average, over the past year
- Current DSM-5 moderate or severe Alcohol Use Disorder, as assessed by the Structured Clinical Interview (SCID) for the Diagnostic and Statistical...
- History of bipolar I or psychosis spectrum disorders, as assessed by the SCID for DSM-5 during the screening interview
- Acute suicidality requiring treatment escalation, as assessed during the screening interview
- Currently taking any daily psychotropic medication
- Failure to meet standard MRI inclusion criteria (i.e., no presence of claustrophobia; cardiac pacemakers; neural pacemakers; surgical clips in the...
See the full eligibility criteria
- Meets criteria for current, severe Cannabis Use Disorder (CUD), as assessed by the Structured Clinical Interview (SCID) for the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) during the...
- Reports engagement in cannabis use at least four days per week, on average, over the past year
- Provide a urine sample positive for tetrahydrocannabinol (THC)
- Able to read and write in English
- Has used cannabis at least 20 days in the past month
- Endorses at least 10 distinct (of 40 possible) cannabis use-related problems across the screening interview and Lab Visit 1 questionnaires
- Other non-cannabis illicit substance use more than once per month, on average, over the past year
- Current DSM-5 moderate or severe Alcohol Use Disorder, as assessed by the Structured Clinical Interview (SCID) for the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) during the screening...
- History of bipolar I or psychosis spectrum disorders, as assessed by the SCID for DSM-5 during the screening interview
- Acute suicidality requiring treatment escalation, as assessed during the screening interview
- Currently taking any daily psychotropic medication
- Failure to meet standard MRI inclusion criteria (i.e., no presence of claustrophobia; cardiac pacemakers; neural pacemakers; surgical clips in the brain or blood vessels; surgically implanted metal plates, screws, or...
- Medical contraindications for transcranial magnetic stimulation (TMS; i.e., presence of a neurological disorder known to alter risk for seizures [e.g., stroke, aneurysm, brain surgery, structural brain lesion, brain...
- History of allergies to cosmetics/lotions or EEG gel
- History of migraines
- Currently engaged in treatment for Cannabis Use Disorder
The study team makes the final eligibility decision.
Where it's taking place
- Auburn, Alabama, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 50 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Auburn, Alabama, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.