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New treatment option for Mild Cognitive Impairment
Official title Observation of Inhalation of CXMCI-01 Essential Oil on Patients With Mild Cognitive Impairment
ClinicalTrials.gov ID: NCT06902181
What this study is testing
- What it's testing
- Memory declined and cognitive impairment are common complaints in neurology clinics. Before diagnosing as dementia, individuals will undergo a transition period, including mild cognitive impairment (MCI).
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 and older
You may be able to join if
- Aged 50 years or older, presenting with memory and cognitive impairment. Diagnosed with Mild Cognitive Impairment (MCI) by a neurologist based on...
- Neurological consultation: Participants must undergo a neurology consultation, including medical history review, neurological examination, and...
- No essential oil use within the past month.
You likely can't join if
- Dementia caused by other conditions, including: Alzheimer's disease, Parkinson's disease, vascular dementia, traumatic brain injury, central nervous...
- Cognitive impairment due to brain lesions, such as: brain tumors, hydrocephalus, severe brain atrophy
- Severe metabolic disorders potentially affecting cognitive function, including:
- Uncontrolled hyperthyroidism or hypothyroidism
- Uncorrected electrolyte imbalance
- Liver dysfunction (ALT or AST \> 1.5× normal upper limit)
See the full eligibility criteria
- Aged 50 years or older, presenting with memory and cognitive impairment. Diagnosed with Mild Cognitive Impairment (MCI) by a neurologist based on clinical and psychological assessment. Mini-mental state...
- Neurological consultation: Participants must undergo a neurology consultation, including medical history review, neurological examination, and olfactory function testing.
- No essential oil use within the past month.
- Dementia caused by other conditions, including: Alzheimer's disease, Parkinson's disease, vascular dementia, traumatic brain injury, central nervous system infections or multiple sclerosis
- Cognitive impairment due to brain lesions, such as: brain tumors, hydrocephalus, severe brain atrophy
- Severe metabolic disorders potentially affecting cognitive function, including:
- Uncontrolled hyperthyroidism or hypothyroidism
- Uncorrected electrolyte imbalance
- Liver dysfunction (ALT or AST \> 1.5× normal upper limit)
- Renal dysfunction (Creatinine \> 1.5× normal upper limit)
- Uncontrolled or poorly managed diabetes (Random glucose \> 200 mg/dL and HbA1c \> 8%)
- Uncontrolled or poorly managed hypertension (SBP \> 160 mmHg or DBP \> 100 mmHg)
- Uncorrected vitamin B12 or folate deficiency
- Severe anemia (Hb \< 8 g/dL) or acute bleeding causing Hb \< 8 g/dL
- Current severe infection (fever \> 38°C, ongoing antibiotic use, or abnormal WBC count)
- Body Mass Index (BMI) ≥ 35
- Severe nasal or pharyngeal diseases affecting olfactory function, or history of asthma attacks in the past six months.
- Substance or alcohol abuse within the past two years, meeting DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) criteria.
- Diagnosis of psychiatric disorders within the past year, including: Major depressive disorder, schizophrenia, bipolar disorder (DSM-5 criteria),
- Severe insomnia, defined as: (1) Experiencing insomnia symptoms for more than 50% of days per month for at least three months, causing daytime fatigue. (2) Use of three or more sleep-related medications (e.g...
The study team makes the final eligibility decision.
Where it's taking place
- Taichung, Taiwan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Taichung, Taiwan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.