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New treatment option for Osteoarthritis, Knee
Official title Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
ClinicalTrials.gov ID: NCT06887829
What this study is testing
- What it's testing
- The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis. A secondary aim is to determine whether patients experience any more measurable side effects than those receiving sham treatments.
- Time commitment: about 2 weeks
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 100
You may be able to join if
- patient's primary care provider is at Mayo Clinic in Rochester, MN
- age 50-100 years
- ICOAP pain scale A1 at least moderate intensity or B6 at least moderate intensity
- diagnosed with primary knee OA ICD-10 codes M17.x o You have not had recurrent episodes of sudden onset of warmth, redness, or swelling of the...
- physical exam findings of medial or lateral joint line tenderness on palpation that is in the same location as the knee pain.
You likely can't join if
- Kellgren-Lawrence grade 1 or 4
- pregnancy or women 54 years and younger with potential for pregnancy (if they or their partner have not had tubal ligation, hysterectomy, or...
- history of ipsilateral intraarticular knee surgery
- use of injected corticosteroids within 3 months or hyaluronans within 6 months or within 1 month if there was no sustained improvement post-injection...
- history of trauma to this knee in the last year that clearly caused the pain now present
- history of RA, gout, pseudogout, hemarthroses (eg, hemophilic arthropathy) or other inflammatory arthritis involving this knee
See the full eligibility criteria
- patient's primary care provider is at Mayo Clinic in Rochester, MN
- age 50-100 years
- ICOAP pain scale A1 at least moderate intensity or B6 at least moderate intensity
- diagnosed with primary knee OA ICD-10 codes M17.x o You have not had recurrent episodes of sudden onset of warmth, redness, or swelling of the affected knee
- physical exam findings of medial or lateral joint line tenderness on palpation that is in the same location as the knee pain.
- absence of primary knee pain in the pes anserine or hamstring or gastrocnemius, quadriceps, or patellar tendons on exam.
- radiographic Kellgren-Lawrence grade 2-3 on 4-view knee x-rays taken within the last year ability to complete surveys electronically by email
- Kellgren-Lawrence grade 1 or 4
- pregnancy or women 54 years and younger with potential for pregnancy (if they or their partner have not had tubal ligation, hysterectomy, or vasectomy)
- history of ipsilateral intraarticular knee surgery
- use of injected corticosteroids within 3 months or hyaluronans within 6 months or within 1 month if there was no sustained improvement post-injection of either corticosteroid or hyaluronan.
- history of trauma to this knee in the last year that clearly caused the pain now present
- history of RA, gout, pseudogout, hemarthroses (eg, hemophilic arthropathy) or other inflammatory arthritis involving this knee
- history of symptomatic hip OA
- history of psychosis, personality disorder, uncontrolled affective disorder
- history of fibromyalgia
- malignancy requiring active treatment current regular use of opiate analgesics, PRP, or acupuncture for the knees
The study team makes the final eligibility decision.
Where it's taking place
- Rochester, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 2 weeks per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 100 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Rochester, Minnesota, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.