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New treatment option for Large Vessel Vasculitis
Official title Dapagliflozin and Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV)
ClinicalTrials.gov ID: NCT06887062
What this study is testing
What is Bosentan and dapagliflozin?
Bosentan and dapagliflozin is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for large vessel vasculitis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Large vessel vasculitis (LVV) is a disease that causes damage to blood vessels. This damage to blood vessels can increase the risk of patients with LVV developing cardiovascular disease, including heart attacks and strokes.
- Phase 2: a mid-size study of how well it works
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- A diagnosis of large vessel vasculitis that has been in remission for ≥ 6 months.
You likely can't join if
- Age \<18 years
- Active LVV
- Any organ transplant recipients
- A requirement for any medications that are contra-indicated whilst taking Bosentan or dapagliflozin
- Congestive cardiac failure
- Patients not medically fit to attend study visits
See the full eligibility criteria
- A diagnosis of large vessel vasculitis that has been in remission for ≥ 6 months.
- Age \<18 years
- Active LVV
- Any organ transplant recipients
- A requirement for any medications that are contra-indicated whilst taking Bosentan or dapagliflozin
- Congestive cardiac failure
- Patients not medically fit to attend study visits
- Patients without mental capacity or willingness to provide informed consent
- History of multiple and/or severe (clinical judgement as determined by the Investigator) allergic reactions to drugs, including the study drug, or food
- Patients who are pregnant or breast feeding, or those who plan to become pregnant during the study
- Participation in another clinical trial for 28 days before or 90 days after the study period
The study team makes the final eligibility decision.
Where it's taking place
- Edinburgh, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Edinburgh, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.