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New treatment option for Aging
Official title Effect of Snacks on Aging
ClinicalTrials.gov ID: NCT06879626
What this study is testing
- What it's testing
- The purpose of this study is to determine if daily consumption of 2 oz of pecans compared to 3.5 oz pretzel snacks for 12 weeks will 1) contribute to the body's ability to protect itself from oxidative damage (caused by oxygen radicals created by ultraviolet (UV) B light) by evaluating skin resistance to UV light irritation, skin fats/oils degradation and "rusting", and oxidative damage to the skin genes; and 2) explore the mechanisms of how snack consumption may affect aging by analyzing blood markers of aging as well as the microbes living in the gut (gut microbiome).
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 55 to 75, women only. Healthy volunteers may be eligible.
You may be able to join if
- Female
- Generally healthy
- Aged 55-75 years
- BMI 18.5-34.9 kg/m2
- Fitzpatrick Skin type II-IV
You likely can't join if
- Vegetarian/vegan
- Known nut allergy
- Skin-related prescription medication, supplements or non-prescription cosmeceutical agents
- Initiation of topical or oral prescription steroids and/or anti-inflammatory medications within 30 days prior to study enrollment
- Excessive exposure to either natural or artificial sunlight
- Screening laboratory values outside of the normal range that is considered clinically significant for study participation by the investigator
See the full eligibility criteria
- Female
- Generally healthy
- Aged 55-75 years
- BMI 18.5-34.9 kg/m2
- Fitzpatrick Skin type II-IV
- Consume a typical Western diet (low in polyphenols-rich foods and fiber)
- Willing to maintain habitual dietary and exercise patterns for the study duration
- Willing to maintain normal skin care products and pattern for the duration of the study
- Willing to come to study visits without any makeup and skin products on
- people must read and sign the Institutional Review Board-approved written informed consent prior to the initiation of any study specific procedures or enrollment. A subject will be excluded for any condition that might...
- Vegetarian/vegan
- Known nut allergy
- Skin-related prescription medication, supplements or non-prescription cosmeceutical agents
- Initiation of topical or oral prescription steroids and/or anti-inflammatory medications within 30 days prior to study enrollment
- Excessive exposure to either natural or artificial sunlight
- Screening laboratory values outside of the normal range that is considered clinically significant for study participation by the investigator
- Documented chronic disease
- Taking medications or supplements known to affect gut microbiota composition (antibiotics within the past 3 months, probiotics, fiber, etc.)
- Taking exogenous hormones (e.g. hormone replacement therapy)
- Recent weight fluctuations (\>10% in the last 6 months)
- Smoker or living with a smoker
- Use of \>20 g of alcohol per day
- Unable or unwilling to comply with the study protocol (including unwillingness to avoid nuts for the whole duration of the study)
- Unable to provide consent
- Pregnancy and/or lactation
The study team makes the final eligibility decision.
Where it's taking place
- Los Angeles, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 55 years to 75 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Los Angeles, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.