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Tests treatment safety and results for Swelling/ Edema
Official title The Efficacy and Safety of Venostan in Promoting Postoperative Swelling Reduction in Patients With Ankle Fractures
ClinicalTrials.gov ID: NCT06872034
What this study is testing
What is Venostasin (horse chestnut seed extract tablets)?
Venostasin (horse chestnut seed extract tablets) is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for swelling/ edema.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is a multicenter, open-label, randomized controlled trial planned to enroll patients with ankle fractures who meet the inclusion and exclusion criteria and are scheduled to undergo internal fixation surgery from the emergency and inpatient wards of multiple hospitals. General and disease-related data will be collected.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- ≥18 year old, no gender restriction;
- Diagnosed with ankle fracture confirmed by imaging data, AO classification: ---AO-43, AO-44-F3, AO-44;
- Scheduled to undergo open reduction and internal fixation surgery;
- Voluntary signing of the informed consent form.
You likely can't join if
- Pregnant or lactating women;
- With contraindications to surgery;
- With other severe combined injuries or soft tissue infections;
- Severe multiple trauma: Injury Severity Score (ISS) \> 16;
- With concurrent fractures of the spine, pelvis, or ipsilateral or contralateral lower limbs;
- Pathological fractures;
See the full eligibility criteria
- ≥18 year old, no gender restriction;
- Diagnosed with ankle fracture confirmed by imaging data, AO classification: ---AO-43, AO-44-F3, AO-44;
- Scheduled to undergo open reduction and internal fixation surgery;
- Voluntary signing of the informed consent form.
- Pregnant or lactating women;
- With contraindications to surgery;
- With other severe combined injuries or soft tissue infections;
- Severe multiple trauma: Injury Severity Score (ISS) \> 16;
- With concurrent fractures of the spine, pelvis, or ipsilateral or contralateral lower limbs;
- Pathological fractures;
- With peripheral vascular disease or deep vein thrombosis (DVT);
- With severe impairment of heart, lung, liver, or kidney function or abnormal coagulation function;
- Unable to walk independently before the injury;
- With pre-existing lower limb edema (e.g., due to liver cirrhosis, kidney disease, etc.) before the injury;
- With mental disorders or hyperalgesia;
- Allergic to any component of the investigational drug;
- Any contraindications that limit clinical evaluation and treatment of the patient;
- Deemed unsuitable for inclusion in this study by the investigator.
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, China
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.