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New treatment option for Coronary Arterial Disease (CAD)
Official title Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
ClinicalTrials.gov ID: NCT06864234
What this study is testing
What is Saline (NaCl)?
Saline (NaCl) is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for coronary arterial disease (cad).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA). The main questions it aims to answer are: Do beta-blockers improve coronary blood flow in patients with ANOCA?
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Patients undergoing diagnostic coronary angiography for suspected angina pectoris who are found to have ANOCA i.e. an FFR \>0.80 and no diameter...
- Normal, TIMI 3 flow at angiography
- Stable haemodynamics
You likely can't join if
- Clinical signs or symptoms of congestive heart failure
- Severe valvular heart disease requiring either surgical or percutaneous intervention
- History of coronary artery bypass grafting
- Tortuous coronary anatomy in which wire manipulation could be complex
- Heart rate \<60 beats per minute
- Systolic blood pressure \<100 mmHg
See the full eligibility criteria
- Patients undergoing diagnostic coronary angiography for suspected angina pectoris who are found to have ANOCA i.e. an FFR \>0.80 and no diameter stenosis \>50%
- Normal, TIMI 3 flow at angiography
- Stable haemodynamics
- Clinical signs or symptoms of congestive heart failure
- Severe valvular heart disease requiring either surgical or percutaneous intervention
- History of coronary artery bypass grafting
- Tortuous coronary anatomy in which wire manipulation could be complex
- Heart rate \<60 beats per minute
- Systolic blood pressure \<100 mmHg
- Unable to give consent
- LVEF\<40%
The study team makes the final eligibility decision.
Where it's taking place
- Aalst, Flanders, Belgium
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Aalst, Flanders, Belgium. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.