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Official title THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy
ClinicalTrials.gov ID: NCT06859710
What this study is testing
What is THC?
THC is an investigational medicine, being studied as a potential treatment for abuse, drug.
Also referred to as Cannabis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this research is to assess the impact of CBD on the effects of THC.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 55. Healthy volunteers may be eligible.
You may be able to join if
- Male or non-pregnant and non-lactating females aged 21-55 years
- Report cannabis use 1-7 days per week over the month prior to screening
- Not currently seeking treatment for their cannabis use
- History of inhaled cannabis use
- Have a Body Mass Index from 18.5 - 34 kg/m2
You likely can't join if
- Meeting DSM-V criteria for severe Cannabis Use disorder (CUD) or any substance use disorder other than nicotine, caffeine, mild or moderate CUD
- Evidence of severe psychiatric illness (e.g. mood or anxiety disorder with functional impairment or suicide risk, schizophrenia) judged by the study...
- Report using other illicit drugs in the prior 4 weeks
- Current pain
- Pregnancy
- Currently enrolled in another research protocol
See the full eligibility criteria
- Male or non-pregnant and non-lactating females aged 21-55 years
- Report cannabis use 1-7 days per week over the month prior to screening
- Not currently seeking treatment for their cannabis use
- History of inhaled cannabis use
- Have a Body Mass Index from 18.5 - 34 kg/m2
- Able to perform all study procedures
- Must be using a contraceptive (hormonal or barrier methods)
- Meeting DSM-V criteria for severe Cannabis Use disorder (CUD) or any substance use disorder other than nicotine, caffeine, mild or moderate CUD
- Evidence of severe psychiatric illness (e.g. mood or anxiety disorder with functional impairment or suicide risk, schizophrenia) judged by the study physician (and PI) to put the participant at greater risk of...
- Report using other illicit drugs in the prior 4 weeks
- Current pain
- Pregnancy
- Currently enrolled in another research protocol
- Not using a contraceptive method (hormonal or barrier methods)
- Insensitivity to the cold water stimulus of the Cold Pressor Test
- Any disorders that might make cannabis administration hazardous as determined by evaluation physician after review of all medical assessments along with medical history.
- Not able to speak and read English
The study team makes the final eligibility decision.
Where it's taking place
- Los Angeles, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 55 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Los Angeles, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.