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New treatment option for Primary Hyperparathyroidism
Official title Bisphosphonate Prior to Parathyroidectomy in Primary Hyperparathyroidism
ClinicalTrials.gov ID: NCT06859580
What this study is testing
What is Zoledronic acid 4 mg?
Zoledronic acid 4 mg is an investigational medicine, given as an once-daily infusion into a vein, being studied as a potential treatment for primary hyperparathyroidism.
Also referred to as ZOL, Zoledronate.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is a randomized, double-blinded, placebo-controlled trial investigating the effects of zoledronic acid (ZOL) versus placebo in patients with primary hyperparathyroidism (PHPT) undergoing parathyroidectomy (PTX). PHPT is a common endocrine disorder associated with hypercalcemia, reduced bone mineral density (BMD), increased fracture risk, renal calcifications, and cardiovascular complications.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 and older
You may be able to join if
- Postmenopausal females or males \> 50 years
- A diagnosis of hyperparathyroid hypercalcemia due to sporadic PHPT referred to PTX
- aBMD T-score ≤ -1 at total hip, femoral neck, or lumbar spine
- 25-hydroxyvitamin D ≥ 50 nmol/l prior to randomization
- Willingness to undergo PTX
You likely can't join if
- Known or suspected familial ethology (e.g., MEN1 or 2)
- Estimated glomerular filtration rate \< 35 ml/min
- Known allergy to bisphosphonates
- Planned or recent (within the last 3 months) major dental procedures (e.g., jaw surgery or tooth extraction)
- Chronic or acute disorders (e.g., rheumatoid arthritis, inflammatory bowel disease, cancer) or prior medications (e.g., lithium, glucocorticoids...
The study team makes the final eligibility decision.
Where it's taking place
- Aarhus N, Central Region of Denmark, Denmark
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Aarhus N, Central Region of Denmark, Denmark. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.