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New treatment option for Endometrioid Ovarian Cancer
Official title Cirtuvivint/Olaparib in Breast Cancer Susceptibility Gene/Homologous Recombination Deficiency Platinum Resistant Ovarian Cancer
ClinicalTrials.gov ID: NCT06856499
What this study is testing
What is Cirtuvivint?
Cirtuvivint is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for endometrioid ovarian cancer.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to learn about the safety and tolerability of Cirtuvivint in combination with Olaparib in platinum resistant ovarian cancer. The study also aims to determine the recommended dose of the combination therapy.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older, women only
You may be able to join if
- Provision to sign and date the consent form.
- Stated willingness to comply with all study procedures and be available for the duration of the study.
- Woman aged ≥18 years of age
- Patients must have an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 1 or 2
- Patients must have a confirmed diagnosis of high-grade serous or endometrioid epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube...
You likely can't join if
- Patients with clear cell, mucinous, sarcomatous, low grade/borderline, germ cell, or sex-cord stromal type ovarian tumor
- Patients with platinum refractory disease as defined by those who have progressed during or within 4 weeks of receiving platinum-based therapy
- Patients receiving any systemic chemotherapy or radiotherapy (except for palliative reasons) within 3 weeks prior to study treatment
- Patients with myelodysplastic syndrome/acute myeloid leukemia or with features suggestive of myelodysplastic syndrome/acute myeloid leukemia.
- Patients considered a poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled...
- Uncontrolled major seizure disorder
See the full eligibility criteria
Who can join
- Provision to sign and date the consent form.
- Stated willingness to comply with all study procedures and be available for the duration of the study.
- Woman aged ≥18 years of age
- Patients must have an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 1 or 2
- Patients must have a confirmed diagnosis of high-grade serous or endometrioid epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer
- Patients must have platinum-resistant disease defined as radiographic progression less than 6 months from last dose of most recent platinum therapy
- Patients must have measurable disease by defined RECIST 1.1 criteria
- Prior anticancer therapy:
- Patients must have received at least one prior platinum-based chemotherapy regimen
- Patients may not have received more than 3 prior lines of systemic therapy
- Neoadjuvant +/- adjuvant therapies are considered 1 line of therapy
- Maintenance therapy (eg, Bevacizumab, PARP inhibitors) will be considered part of preceding line of therapy (ie, not counted independently)
- Therapy changed due to toxicity in the absence of progression will be considered part of the same line (ie, not counted independently)
- Hormonal therapy will be counted as a separate line of therapy unless it was given as maintenance
- Prior radiation is allowed and is not considered a line of treatment
- Patients must have had testing for BRCA mutation (tumor or germline) and tumor HRD testing, and have been positive for one and/or the other.
- Patients must have received a prior PARP inhibitor as either treatment or maintenance therapy
- Patients must have adequate hematologic, liver, and kidney function as defined as:
- Absolute neutrophil count (ANC) ≥ 1.5 x 109/L (1500/µL)
- Platelet count ≥ 100 x 109/L (100,000 µL)
- Hemoglobin ≥ 10.0 g/dL with no blood transfusion in the past 28 days
- Serum creatinine ≤ 1.5 x upper limit of normal (ULN)
- Patients must have creatinine clearance estimated of ≥51 mL/min using the Cockcroft-Gault equation or based on a 24 hour urine test
- Aspartate aminotransferase (AST)(Serum Glutamic Oxaloacetic Transaminase (SGOT)) and alanine aminotransferase (ALT) (Serum Glutamic Pyruvate Transaminase (SGPT)) ≤ 2.5 x ULN unless liver metastases are present in which...
- Serum bilirubin ≤ 1.5 x ULN (patients with documented diagnosis of Gilbert syndrome are eligible if total bilirubin \< 3.0 x ULN)
- Serum albumin ≥ 2 g/dL
- Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or how well it works assessment of the investigational regimen are eligible for...
- Ability to understand and the willingness to sign a written informed consent document. Participants with impaired decision-making capacity (IDMC) who have a legally-authorized representative (LAR) and/or family member...
What rules you out
- Patients with clear cell, mucinous, sarcomatous, low grade/borderline, germ cell, or sex-cord stromal type ovarian tumor
- Patients with platinum refractory disease as defined by those who have progressed during or within 4 weeks of receiving platinum-based therapy
- Patients receiving any systemic chemotherapy or radiotherapy (except for palliative reasons) within 3 weeks prior to study treatment
- Patients with myelodysplastic syndrome/acute myeloid leukemia or with features suggestive of myelodysplastic syndrome/acute myeloid leukemia.
- Patients considered a poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled infection. Examples include, but are not limited to:
- Uncontrolled major seizure disorder
- Unstable spinal cord compression
- Any psychiatric disorder that prohibits obtaining informed consent.
- Any other concurrent infectious disease requiring IV antibiotics within 2 weeks prior to the first dose of therapy
- Patients with clinically significant cardiac disease including, but not limited to, any of the following
- Myocardial infarction ≤ 6 months prior to first dose
- Uncontrolled ventricular arrhythmia, recent (within 3 months)
- Superior vena cava syndrome
- Unstable angina pectoris
- Uncontrolled congestive heart failure (New York Heart Association \> class II)
- Uncontrolled ≥ Grade 3 hypertension (per CTCAE)
- Uncontrolled cardiac arrhythmias
- Patients with a history of hemorrhagic or ischemic stroke within 6 months prior to enrollment
- Patients with a history of cirrhotic liver disease (Child-Pugh Class B or C)
- Persistent toxicities (\>/= Common Terminology Criteria for Adverse Event (CTCAE) grade 2) caused by previous cancer therapy, excluding alopecia or peripheral sensory neuropathy
- Patients with duodenal stent or other GI disorder/defect that would interfere with absorption of oral medication o Includes patients unable to swallow orally administered medication and patients with gastrointestinal...
- Patients with known untreated or symptomatic central nervous system (CNS) metastases
- Prior known hypersensitivity reaction to study drugs and/or any of their excipients
- Minor or major surgical procedure within 2 weeks of starting study treatment and patients must have recovered from any effects of any major surgery.
- Inability to comply with study and follow-up procedures
- Patients deemed otherwise clinically unfit for clinical trial per investigators discretion.
The study team makes the final eligibility decision.
Where it's taking place
- Aurora, Colorado, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Aurora, Colorado, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.