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New treatment option for Ischemic Heart Disease (IHD)
Official title The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
ClinicalTrials.gov ID: NCT06854458
What this study is testing
What is Gadavist?
Gadavist is an investigational medicine, being studied as a potential treatment for ischemic heart disease (ihd).
Also referred to as Gadobutrol.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in the coronary blood vessels or inflammation of the heart using cardiac magnetic resonance imaging that measures the amount of blood flow during a stress state meant to simulate vigorous exercise. At present, doctors use standard magnetic resonance imaging pictures of blood flow patterns to treat heart disease.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 35 to 85
You may be able to join if
- male or female at age 35-85 years,
- presence of either of the following sign/symptom that led to a referral to stress cardiac magnetic resonance imaging:
- chest pain or anginal equivalent, or
- abnormal electrocardiogram with a suspicion of coronary artery disease
- Intermediate or high risk of significant coronary disease based on at least 1 of the following conditions: a) patient age \> 45 for male, 50 for...
You likely can't join if
- Acute myocardial infarction within the past 30 days prior to cardiac magnetic resonance imaging
- Confirmed diagnosis of any significant non-coronary cardiac conditions below:
- any severe-grade valvular heart disease,
- left ventricular ejection fraction \<40% from any known non-coronary causes,
- infiltrative cardiomyopathy,
- hypertrophic cardiomyopathy,
See the full eligibility criteria
- male or female at age 35-85 years,
- presence of either of the following sign/symptom that led to a referral to stress cardiac magnetic resonance imaging:
- chest pain or anginal equivalent, or
- abnormal electrocardiogram with a suspicion of coronary artery disease
- Intermediate or high risk of significant coronary disease based on at least 1 of the following conditions: a) patient age \> 45 for male, 50 for female b) Diabetes, hypertension, or hypercholesterolemia: by either...
- Acute myocardial infarction within the past 30 days prior to cardiac magnetic resonance imaging
- Confirmed diagnosis of any significant non-coronary cardiac conditions below:
- any severe-grade valvular heart disease,
- left ventricular ejection fraction \<40% from any known non-coronary causes,
- infiltrative cardiomyopathy,
- hypertrophic cardiomyopathy,
- pericardial disease with significant constriction, or
- active pregnancy,
- any competing conditions leading to an expected survival of \< 2 years
- contraindication to vasodilator (regadenoson or adenosine)
- metallic device or object that poses an magnetic resonance imaging safety hazard
- metallic device with a high likelihood of non-diagnostic cardiac magnetic resonance images
The study team makes the final eligibility decision.
Where it's taking place
- San Francisco, California, United States
- Louisville, Kentucky, United States
- Boston, Massachusetts, United States
- Roslyn, New York, United States
- Charlotte, North Carolina, United States
- Cleveland, Ohio, United States
- Columbus, Ohio, United States
- Nashville, Tennessee, United States
- Houston, Texas, United States
- Charlottesville, Virginia, United States
- Richmond, Virginia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 35 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include San Francisco, California, United States; Louisville, Kentucky, United States; Boston, Massachusetts, United States; Roslyn, New York, United States; Charlotte, North Carolina, United States; Cleveland, Ohio, United States and 5 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.