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New treatment option for Chronic Hepatitis B Virus
Official title Gene Discovery in CHB Patients to Identify Unknown Pathways That Lead to B and NK Cell Deregulation
ClinicalTrials.gov ID: NCT06853886
What this study is testing
- What it's testing
- Natural Killer (NK) and B cell immune responses occur during the early stages of infection and are essential to eradicate it. Yet, chronic hepatitis B (CHB) infection occurs because the antiviral immune response is insufficient.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Male or female, age ≥18 years old
- HBV infection or chronic HBV infection untreated or treated with a nucleoside or nucleotide analog
- Willing and able to provide written informed consent
- Affiliated with a social securityregimen Healthy volunteer must meet all of the following to be eligible for participation in this study:
- Male or female, age between 18 and 80 years
You likely can't join if
- Co-infection with HCV, HIV or HDV (or HBV for healthy volunteer)
- Acute hepatitis in the year preceding recruitment
- Other liver diseases : alcohol, obesity (BMI\>30), diabetes, metabolic syndrome (dyslipidemia and/or known hypertension) - Underlying immunological...
- Patient with a disability that prevents him/her from fully understanding the requirements of the trial - Patient under court protection, guardianship...
- Pregnant or breast-feeding women. Secondary exclusion criteria:
- A healthy volunteer whose vaccination status does not match that expected on the basis of serological results
See the full eligibility criteria
- Male or female, age ≥18 years old
- HBV infection or chronic HBV infection untreated or treated with a nucleoside or nucleotide analog
- Willing and able to provide written informed consent
- Affiliated with a social securityregimen Healthy volunteer must meet all of the following to be eligible for participation in this study:
- Male or female, age between 18 and 80 years
- Willing and able to provide written informed consent
- Co-infection with HCV, HIV or HDV (or HBV for healthy volunteer)
- Acute hepatitis in the year preceding recruitment
- Other liver diseases : alcohol, obesity (BMI\>30), diabetes, metabolic syndrome (dyslipidemia and/or known hypertension) - Underlying immunological or cancerous diseases
- Patient with a disability that prevents him/her from fully understanding the requirements of the trial - Patient under court protection, guardianship or curatorship
- Pregnant or breast-feeding women. Secondary exclusion criteria:
- A healthy volunteer whose vaccination status does not match that expected on the basis of serological results
- Positive blood pregnancy test on inclusion
- Positive HCV, HIV or HDV test in a patient
- Positive HBV, HCV, HIV or HDV test in a healthy volunteer
The study team makes the final eligibility decision.
Where it's taking place
- Limoges, France
- Lyon, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Limoges, France; Lyon, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.