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New treatment option for Septic Shock
Official title Impact of Vascular Calcification and CASR Expression by Monocytes in Septic Shock
ClinicalTrials.gov ID: NCT06853340
What this study is testing
What is blood sampling?
blood sampling is an investigational medicine, being studied as a potential treatment for septic shock.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- In septic shock, bacterial LPS is able to activate the CaSR of cardiomyocytes inducing their apoptosis in vitro. CaSR activation in monocytes is responsible for activation of the NLRP3 inflammasome and macropinocytosis.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Male or female patients over the age of 18,
- patients who have not participated in a study evaluating an investigational drug in the 30 days preceding the samples,
- intensive care patients in a state of septic shock within the first 24 hours of the introduction of pressor amines,
- French resident year-round,
- lactate \> 2mmol/L,
You likely can't join if
- Patients in hemorrhagic shock,
- history of parathyroidectomy, patient with hypersecretion of PTHrp,
- sarcoidosis,
- genetic disturbance of CaSR including familial hypocalciuric hypercalcaemia,
- current immunosuppressant treatment (anticalcineurin, mTOR inhibitor, methotrexate, high-dose corticosteroids excluding hydrocortisone and...
- chronic myelomonocytic leukemia,
See the full eligibility criteria
- Male or female patients over the age of 18,
- patients who have not participated in a study evaluating an investigational drug in the 30 days preceding the samples,
- intensive care patients in a state of septic shock within the first 24 hours of the introduction of pressor amines,
- French resident year-round,
- lactate \> 2mmol/L,
- patients with social security coverage.
- Patients in hemorrhagic shock,
- history of parathyroidectomy, patient with hypersecretion of PTHrp,
- sarcoidosis,
- genetic disturbance of CaSR including familial hypocalciuric hypercalcaemia,
- current immunosuppressant treatment (anticalcineurin, mTOR inhibitor, methotrexate, high-dose corticosteroids excluding hydrocortisone and fludrocortisone),
- chronic myelomonocytic leukemia,
- patients with febrile neutropenia,
- patients with acquired or constitutional immune system,
- pregnant or breastfeeding patient,
- patients under curators, guardianship or safeguard of justice.
The study team makes the final eligibility decision.
Where it's taking place
- Amiens, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Amiens, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.