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Compares treatment options for Obesity and Overweight
Official title Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder
ClinicalTrials.gov ID: NCT06847399
What this study is testing
What is Tirzepatide?
Tirzepatide is an investigational medicine, being studied as a potential treatment for obesity and overweight.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to assess the efficacy and safety of tirzepatide in adults with obesity and binge-eating disorder, comparing tirzepatide against placebo and lisdexamfetamine dimesylate. All participants will receive guided self-help cognitive behavioral therapy.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Disease Characteristics
- Have a BMI ≥30 kg/m2 or ≥27 kg/m2
- previously diagnosed with at least one obesity-related comorbidity:
- Have at least one self-reported unsuccessful dietary effort to lose body weight
- Meet Diagnostic and Statistical Manual (DSM)-5 criteria for Binge Eating Disorder (BED) as diagnosed by the Eating Disorder Examination interview and...
You likely can't join if
- Medical Conditions Eating disorder-related
- Current diagnosis of bulimia nervosa or anorexia nervosa Diabetes-related
- Have type 1 diabetes mellitus (T1DM) or Type 2 diabetes mellitus (T2DM), history of ketoacidosis, or hyperosmolar state/coma
- Have laboratory evidence diagnostic of diabetes mellitus during screening, including an HbA1c ≥6.5% or fasting glucose \>126 mg/dL Obesity-related:
- Have a self-reported change in body weight \>5 kg within 3 months prior to screening
- Have a prior or planned surgical treatment for obesity (excluding lap-band if removed \>6 months prior to screening or liposuction or abdominoplasty...
See the full eligibility criteria
Who can join
- Disease Characteristics
- Have a BMI ≥30 kg/m2 or ≥27 kg/m2
- previously diagnosed with at least one obesity-related comorbidity:
- Have at least one self-reported unsuccessful dietary effort to lose body weight
- Meet Diagnostic and Statistical Manual (DSM)-5 criteria for Binge Eating Disorder (BED) as diagnosed by the Eating Disorder Examination interview and confirmed by binge-eating diaries that is moderate or greater in...
- Are 18 years of age or older
- Participants assigned female at birth: (participants assigned female at birth who are not of childbearing potential may participate and include those who are:
- infertile due to surgical sterilization (hysterectomy, bilateral oophorectomy or tubal ligation), congenital anomaly such as Mullerian agenesis
- postmenopausal, defined as either
- a female at least 40 years of age with an intact uterus, not on hormone therapy and who has cessation of menses for at least 1 year without an alternative medical cause; women in this category must test negative in...
- a female 55 or older not on hormone therapy, who has had at least 12 months of spontaneous amenorrhea OR
- a female at least 55 years of age with a diagnosis of menopause prior to starting hormone replacement therapy Participants assigned female at birth of child-bearing potential (not surgically sterilized and between...
- test negative for pregnancy at Visit 1 based on a serum pregnancy test
- and if sexually active, agree in writing to use 2 forms of effective contraception, where at least 1 form is highly effective, for the duration of the trial
- not be breastfeeding Informed Consent
- Understand and be willing to comply with all study-related procedures and agree to participate in the study by giving written informed consent in accordance with local regulations
- In the investigator's opinion, are well-motivated, capable, and willing to:
- Learn how to self-inject study drug, as required for this protocol (persons with visual impairments or physical limitations who are not able to perform the injections must have the assistance of an individual trained to...
- Inject study drug (or receive an injection from a trained individual if visually impaired or with physical limitations)
- Learn how to take oral capsules, be consistently able to swallow capsules, and willing to take oral capsules daily as required for this protocol
- Follow study procedures for the duration of the study
What rules you out
- Medical Conditions Eating disorder-related
- Current diagnosis of bulimia nervosa or anorexia nervosa Diabetes-related
- Have type 1 diabetes mellitus (T1DM) or Type 2 diabetes mellitus (T2DM), history of ketoacidosis, or hyperosmolar state/coma
- Have laboratory evidence diagnostic of diabetes mellitus during screening, including an HbA1c ≥6.5% or fasting glucose \>126 mg/dL Obesity-related:
- Have a self-reported change in body weight \>5 kg within 3 months prior to screening
- Have a prior or planned surgical treatment for obesity (excluding lap-band if removed \>6 months prior to screening or liposuction or abdominoplasty if performed \>1 year prior to screening)
- Have or plan to have endoscopic and/or device-based therapy for obesity or have had device removal within the last 6 months prior to screening (for example, mucosal ablation, gastric artery embolization, intragastric...
- Have a family or personal history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia (MEN) Syndrome type 2
- Known serious hypersensitivity to tirzepatide or lisdexamfetamine dimesylate or any of the excipients in the medications
- Have severe gastrointestinal disease
- Have known clinically significant renal impairment
- Have uncontrolled medical conditions or contraindications to tirzepatide or lisdexamfetamine dimesylate
- Have personal or family history of cardiovascular disease that could increase vulnerability to sympathomimetic effects of psychostimulants
- Have a history of suspected substance abuse within the past 5 years
- Have a lifetime history of psychostimulant abuse and/or dependence
- Have glaucoma
- Have had a history of chronic or acute pancreatitis
- Have obesity induced by other endocrinologic disorders (for example, Cushing Syndrome) or diagnosed monogenetic or syndromic forms of obesity (for example, Melanocortin 4 Receptor deficiency or Prader Willi Syndrome)
- Have a current diagnosis of attention-deficit/hyperactivity disorder
- Have a history of significant active or unstable Major Depressive Disorder (MDD; within the last 2 years) or other severe psychiatric disorder (for example, schizophrenia, bipolar disorder, psychosis, mania, hypomania...
- Have a Patient Health Questionnaire-9 (PHQ-9) score of 15 or more at Visit 1 or 2, prior to randomization
- Have any lifetime history of a suicide attempt
- Individual is considered a suicide risk in the opinion of the investigator; or endorsement of current, active suicidal ideation at screening or randomization. On the Columbia-Suicide Severity Rating Scale (C-SSRS) at...
- a "yes" answer to either Question 4 (Active Suicidal Ideation with Some Intent to Act, Without Specific Plan) or
- a "yes" answer to Question 5 (Active Suicidal Ideation with Specific Plan and Intent) on the "Suicidal Ideation" portion of the C-SSRS or
- a "yes" answer to any of the suicide-related behaviors (Actual Attempt, Interrupted Attempt, Aborted Attempt, Preparatory Act or Behavior) on the "Suicidal Behavior" portion of the C-SSRS and
- the ideation or behavior occurred within the past month
- Have taken monoamine oxidate inhibitors (MAOI), or within 14 days of stopping MAOIs
- Have uncontrolled hypertension (SBP above or equal to 160 mmHg and/or diastolic blood pressure above or equal to 100 mmHg)
- Have any of the following cardiovascular conditions within 3 months prior to randomization: acute myocardial infarction (MI), cerebrovascular accident (stroke), unstable angina
- Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy (other than basal- or squamous-cell skin cancer, in situ carcinomas of the cervix, or in situ prostate...
- History of seizures (other than infantile febrile seizures), any tic disorder, or a current diagnosis and/or known family history of Tourette's Disorder, serious neurological disease, history of significant head trauma...
- Participant has known history of symptomatic cardiovascular disease, advanced arteriosclerosis, structural cardiac abnormality, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease, or other...
- Have a history of any other condition that, in the opinion of the investigator, may preclude the participant from following and completing the protocol Prior/Concomitant Therapy
- Are receiving concurrent treatment for eating or weight disorders
- Use of a psychostimulant within the past 6 months
- Have taken within 3 months prior to screening, medications (prescribed or over-the counter) intended to promote weight loss. Examples include, but are not limited to
- Saxenda® (liraglutide 3.0 mg)
- Xenical®/Alli® (orlistat)
- Meridia® (sibutramine)
- Adipex® (phentermine)
- BELVIQ® (lorcaserin)
- Qsymia® (phentermine/topiramate combination)
- Contrave® (naltrexone/bupropion)
- Ozempic or Wegovy (semaglutide)
- Mounjaro or Zepbound (tirzepatide)
- Rybelsus (semaglutide) Prior/Concurrent Clinical Study Experience
- Are currently enrolled in any other clinical study involving an investigational product (IP) or any other type of medical research judged not to be scientifically or medically compatible with this study
The study team makes the final eligibility decision.
Where it's taking place
- Baltimore, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baltimore, Maryland, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.