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New treatment option for Charcot-Marie-Tooth Neuropathy Type 1A
Official title Longitudinal Quantitative Neuromuscular MRI in Neuropathic Patients
ClinicalTrials.gov ID: NCT06845644
What this study is testing
- What it's testing
- The pathophysiological process common to neuropathies is fatty replacement of muscle tissue, more commonly known as intramuscular fat fraction (F.F). MRI is an imaging technique that enables us to distinguish between muscle and fat tissue, and thus to objectify in vivo structural changes within nerves and muscles in neuropathic patients.
- Time commitment: about 12 months
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Male or female between 18 and 80 years of age,
- Patients who have freely given their consent to participate in this study,
- Patient with genetically confirmed hereditary CMT neuropathy
- or patient with an acquired demyelinating neuropathy such as typical PIDC or anti-MAG of typical form
- or a patient with a genetically confirmed pathogenic mutation in the transthyretin (TTRn) gene,
You likely can't join if
- Patients with co-morbidity or a history of other peripheral neuropathy,
- Patients with alcohol or psychoactive substance abuse,
- Patients with contraindications to MRI exploration: claustrophobia, pacemakers, Holter systems, IUDs, metal surgical clips, metal prostheses or...
- Patient unable to perform the MRI due to severe handicap,
- Patient in a period of exclusion from another research protocol at the time of signing the consent/non-opposition form,
- people covered by articles L1121-5 to 1121-8 of the French Public Health Code (minors, adults under guardianship or trusteeship, patients deprived of...
See the full eligibility criteria
- Male or female between 18 and 80 years of age,
- Patients who have freely given their consent to participate in this study,
- Patient with genetically confirmed hereditary CMT neuropathy
- or patient with an acquired demyelinating neuropathy such as typical PIDC or anti-MAG of typical form
- or a patient with a genetically confirmed pathogenic mutation in the transthyretin (TTRn) gene,
- Patients who are beneficiaries or entitled beneficiaries of a social security scheme.
- Patients with co-morbidity or a history of other peripheral neuropathy,
- Patients with alcohol or psychoactive substance abuse,
- Patients with contraindications to MRI exploration: claustrophobia, pacemakers, Holter systems, IUDs, metal surgical clips, metal prostheses or implants (or other metal foreign bodies),
- Patient unable to perform the MRI due to severe handicap,
- Patient in a period of exclusion from another research protocol at the time of signing the consent/non-opposition form,
- people covered by articles L1121-5 to 1121-8 of the French Public Health Code (minors, adults under guardianship or trusteeship, patients deprived of their liberty, pregnant or breast-feeding women),
- Persons who cannot read and understand the French language well enough to be able to give their consent to participate in research.
The study team makes the final eligibility decision.
Where it's taking place
- Marseille, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 12 months per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Marseille, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.