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Official title A Study to Improve Skeletal Muscle in Veterans With HIV
ClinicalTrials.gov ID: NCT06845046
What this study is testing
- What it's testing
- The Department of Veterans Affairs is the largest single provider of medical care to people with HIV in the United States. The condition of excess lipid within and around muscle, termed myosteatosis, predisposes Veterans to physical function decline, frailty, disability, and cardiometabolic diseases such as diabetes and cardiovascular disease.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 20 to 80, men only
You may be able to join if
- Veteran
- HIV+
- antiretroviral therapy = integrase strand transfer inhibitor for at least 3 months
- HIV-1 RNA \<50 copies/ml
- age = 20 yrs
You likely can't join if
- unstable body weight (gain or loss \> 5% over past 3 months)
- diagnosed mitochondrial disorder
- diagnosed type 1 or type 2 diabetes
- use of metformin or other anti-diabetic agents for pre-diabetes
- hemoglobin A1c of \>6.5% at screening visit
- inflammatory conditions or chronic corticosteroid use
See the full eligibility criteria
- Veteran
- HIV+
- antiretroviral therapy = integrase strand transfer inhibitor for at least 3 months
- HIV-1 RNA \<50 copies/ml
- age = 20 yrs
- BMI 28-50 kg/m2
- unstable body weight (gain or loss \> 5% over past 3 months)
- diagnosed mitochondrial disorder
- diagnosed type 1 or type 2 diabetes
- use of metformin or other anti-diabetic agents for pre-diabetes
- hemoglobin A1c of \>6.5% at screening visit
- inflammatory conditions or chronic corticosteroid use
- stage 3 or greater kidney disease
- dietary or herbal supplements known to affect body weight, muscle mass, or immune function
- MRI incompatibility
- inability to perform physical function tests due to anatomical limitations
- contradictions to CPET such as exercise-induced ischemia or supplemental oxygen
The study team makes the final eligibility decision.
Where it's taking place
- Nashville, Tennessee, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling male, 20 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nashville, Tennessee, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.