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New treatment option for Opioid Use Disorder
Official title The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD)
ClinicalTrials.gov ID: NCT06832007
What this study is testing
- What it's testing
- Opioid use disorder (OUD) is a chronic relapsing disorder and is well-known for its high-risk rate of overdoses and death. In OUD, sleep and circadian disruptions are highly prevalent, interfere with opioid maintenance treatment outcomes and increase the risk of relapse.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60. Healthy volunteers may be eligible.
You may be able to join if
- All Participants
- Between 18 and 60 years old
- Fluent in English
- Able to provide written informed consent OUD
- DSM-5 diagnosis of an OUD.
You likely can't join if
- All Participants
- Head trauma with loss of consciousness for more than 30 minutes as determined by medical history.
- history of seizures/epilepsy.
- Pregnant and/or currently breast-feeding.
- Presence of ferromagnetic objects in the body that are contraindicated for MRI or fear of enclosed spaces.
- Eye disease including disease of the anterior and posterior segment of the eye, cataracts, retinopathy, glaucoma, amblyopia, scotoma, color or night...
See the full eligibility criteria
- All Participants
- Between 18 and 60 years old
- Fluent in English
- Able to provide written informed consent OUD
- DSM-5 diagnosis of an OUD.
- ≥12 months of lifetime opioid use
- Positive on urine drug screen for buprenorphine or methadone
- Receiving opioid agonist therapy for OUD (e.g., methadone or buprenorphine) with a stable dose for the past month. Must have been stabilized on OMT medication, since the increasing of doses during induction phase might...
- Other substance use was not exclusionary, but opioids were identified as primary.
- All Participants
- Head trauma with loss of consciousness for more than 30 minutes as determined by medical history.
- history of seizures/epilepsy.
- Pregnant and/or currently breast-feeding.
- Presence of ferromagnetic objects in the body that are contraindicated for MRI or fear of enclosed spaces.
- Eye disease including disease of the anterior and posterior segment of the eye, cataracts, retinopathy, glaucoma, amblyopia, scotoma, color or night blindness, corneal pathologies, macular degeneration, or retinitis...
- History of eye surgery
- Chronic migraine triggered by bright light
- worked night shift or traveled across\>2 time zones in the past month OUD
- diagnosis of substance use disorder other than for opioids that was deemed to be primary
- lifetime diagnosis of schizophrenia, bipolar disorder, or suicidality.
- History of light treatment
- Unstable dose of psychiatric medication (hypnotics, sleep aids, and antidepressants must be stable for 30 days before and during the study) HC
- Current or past DSM-IV or DSM-5 diagnosis of a psychiatric disorder including substance use disorder (except for nicotine/caffeine).
- Current DSM-5 sleep-wake disorders including insomnia disorder
The study team makes the final eligibility decision.
Where it's taking place
- Birmingham, Alabama, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Birmingham, Alabama, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.