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New treatment option for Alveolar Ridge Preservation
Official title Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preservation
ClinicalTrials.gov ID: NCT06827665
What this study is testing
What is DDA?
DDA is an investigational medicine, being studied as a potential treatment for alveolar ridge preservation.
Also referred to as demineralized dentin allografts (DDA).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- For the first time, allografts from human-extracted teeth will be prepared and evaluated in a prospective clinical trial to assess their efficacy for alveolar ridge preservation. The reconstruction and preservation of the alveolar ridge after tooth extraction are essential for future prosthetic rehabilitation.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60
You may be able to join if
- Inclusion and
You likely can't join if
- for Donors: Inclusion Criteria:
- Students, interns, or residents willing to participate and provide informed consent.
- No history of systemic diseases such as diabetes, hepatitis, or immune disorders.
- Negative blood screening for HIV, HBV, and HCV.
- Non-smokers or individuals who have not smoked within the last six months. Exclusion Criteria:
- History of systemic conditions affecting oral or overall health.
See the full eligibility criteria
- Inclusion and
- for Donors: Inclusion Criteria:
- Students, interns, or residents willing to participate and provide informed consent.
- No history of systemic diseases such as diabetes, hepatitis, or immune disorders.
- Negative blood screening for HIV, HBV, and HCV.
- Non-smokers or individuals who have not smoked within the last six months. Exclusion Criteria:
- History of systemic conditions affecting oral or overall health.
- Positive blood tests for communicable diseases.
- Active oral infections or untreated dental caries.
- Pregnant or lactating individuals.
- Individuals with a history of smoking or substance abuse within the last six months. Inclusion and Exclusion Criteria for Recipients: Inclusion Criteria:
- Patients aged 18-60 years, requiring extraction of at least three teeth for clinical or therapeutic reasons.
- Patients in good systemic health without conditions that impair bone healing.
- Willingness to provide informed consent and participate in follow-ups. Exclusion Criteria:
- Systemic conditions such as diabetes, osteoporosis, or immunodeficiency that could impair bone regeneration.
- Active oral infections at extraction sites.
- History of radiation therapy to the head and neck region.
- Smoking or smoking history within the last six months.
- Use of medications affecting bone metabolism (e.g., bisphosphonates, steroids).
- Pregnancy or lactation. Additional Justification for Extraction: Teeth chosen for extraction must meet one or more criteria:
- Severe periodontal disease.
- Irreversible pulpitis or structural damage.
- Non-restorable condition impacting oral health or functionality.
The study team makes the final eligibility decision.
Where it's taking place
- Amman, Jordan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Amman, Jordan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.