BridgeMD
New treatment option for Abortion, Habitual
Official title Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History
ClinicalTrials.gov ID: NCT06821685
What this study is testing
What is autologous decidual-like NK cells?
autologous decidual-like NK cells is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for abortion, habitual.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The aim of this study is preliminary exploration of the effectiveness and duration of autologous decidual-like NK cells therapy in improving uterine NK cells dysfunction.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 22 to 40, women only
You may be able to join if
- abnormal uterine NK cell function;
- have one of the following medical history: unexplained recurrent spontaneous abortions (≥2 spontaneous abortions, including biochemical pregnancy)...
- have clear fertility desires;
- normal ovarian function or with frozen embryos;
- edometrium thickness measured by vaginal ultrasound before ovulation or at mid-luteal phase \>= 7mm;
You likely can't join if
- using progesterone receptor modulator;
- chromosomal karyotype abnormalities in one spouse;
- severe endometriosis, uterine fibroids affecting the shape of the uterine cavity or the size of the whole uterus more than 2 and a half months of...
- uncontrolled autoimmune diseases;
- abnormal blood coagulation function, abnormal liver and kidney function, or other uncontrolled basic diseases (hypertension, diabetes, thyroid...
- history of pelvic malignant tumors;
See the full eligibility criteria
- abnormal uterine NK cell function;
- have one of the following medical history: unexplained recurrent spontaneous abortions (≥2 spontaneous abortions, including biochemical pregnancy), repeated implantation failure (failure of implantation of good-quality...
- have clear fertility desires;
- normal ovarian function or with frozen embryos;
- edometrium thickness measured by vaginal ultrasound before ovulation or at mid-luteal phase \>= 7mm;
- 18kg/m\^2 \< Body mass index \< 30kg/m\^2;
- using progesterone receptor modulator;
- chromosomal karyotype abnormalities in one spouse;
- severe endometriosis, uterine fibroids affecting the shape of the uterine cavity or the size of the whole uterus more than 2 and a half months of pregnancy, uterine malformation, uterine adhesion or thin endometrium;
- uncontrolled autoimmune diseases;
- abnormal blood coagulation function, abnormal liver and kidney function, or other uncontrolled basic diseases (hypertension, diabetes, thyroid disease, etc.) that the researcher access which may affect the progress of...
- history of pelvic malignant tumors;
- currently participating in other clinical studies;
- allergic to blood products.
The study team makes the final eligibility decision.
Where it's taking place
- Nanjing, Jiangsu, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 22 years to 40 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nanjing, Jiangsu, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.