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New treatment option for Burnout
Official title Psilocybin-Assisted Therapy for Physician Well-Being and Burnout
ClinicalTrials.gov ID: NCT06814522
What this study is testing
What is Psilocybin, [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate?
Psilocybin, [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate is an investigational medicine, being studied as a potential treatment for burnout.
Also referred to as Psilocybin.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Through an open-label study involving a small group of UCSD physicians experiencing burnout, the investigators will evaluate the feasibility, safety, and preliminary effectiveness of PAT to reduce burnout symptoms.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 70
You may be able to join if
- UCSD faculty physician, aged 21-70. Volunteer faculty are not included
- Meets criteria for physician burnout
- Experiencing symptoms of burnout for \>6 months
- Able to complete all required study visits
- Not previously diagnosed with a serious mental illness (including schizophrenia, bipolar disorder, and severe depression), or substance use disorder...
You likely can't join if
- Previous inpatient psychiatric hospitalization(s)
- Previously diagnosed with a psychotic disorder (schizophrenia, schizoaffective disorder, or other psychotic spectrum disorder), bipolar spectrum...
- Exhibiting elevated suicide risk
- First degree family history of psychosis or bipolar disorder
- Prior exposure to psilocybin or other psychedelic compounds in the previous 10 years
- Currently pregnant, nursing, planning pregnancy, engaging in sexual intercourse without effective contraceptive method in last three months
See the full eligibility criteria
- UCSD faculty physician, aged 21-70. Volunteer faculty are not included
- Meets criteria for physician burnout
- Experiencing symptoms of burnout for \>6 months
- Able to complete all required study visits
- Not previously diagnosed with a serious mental illness (including schizophrenia, bipolar disorder, and severe depression), or substance use disorder as confirmed in clinical interview
- Not currently taking any psychotropic medications or nonpsychotropic medication that may be associated with serotonin syndrome, such as serotonin reuptake inhibitors (SSRI or SNRI), dextromethorphan, linezolid...
- Previous inpatient psychiatric hospitalization(s)
- Previously diagnosed with a psychotic disorder (schizophrenia, schizoaffective disorder, or other psychotic spectrum disorder), bipolar spectrum disorder, personality disorder (borderline personality disorder...
- Exhibiting elevated suicide risk
- First degree family history of psychosis or bipolar disorder
- Prior exposure to psilocybin or other psychedelic compounds in the previous 10 years
- Currently pregnant, nursing, planning pregnancy, engaging in sexual intercourse without effective contraceptive method in last three months
- Those who plan to donate sperm within three months following the study.
- Known cardiovascular disease including history of stroke, myocardial infarction, uncontrolled hypertension, valvular heart disease, tachycardia, elongated QT interval, or clinically significant arrythmia.
- History of seizure disorder
- Use of recreational illicit drugs
- Clinically concerning results from vital signs, ECG, physical examination, or laboratory tests during screening
- Any other clinically significant illnesses deemed to pose risk for the participant
The study team makes the final eligibility decision.
Where it's taking place
- San Diego, California, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include San Diego, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.