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New treatment option for Anesthesia
Official title The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
ClinicalTrials.gov ID: NCT06802224
What this study is testing
What is Norepinephrine?
Norepinephrine is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for anesthesia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient recovery.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age 18 years or older
- Surgery under general anesthesia with a surgery duration of 2 hours or more
- Received intravenous vasopressors during surgery
You likely can't join if
- Cardiac surgery
- Extra-corporeal membrane oxygenation
- Organ transplantation
- Obstetric procedures
- Procedures on the kidney
- Outpatient procedures
See the full eligibility criteria
- Age 18 years or older
- Surgery under general anesthesia with a surgery duration of 2 hours or more
- Received intravenous vasopressors during surgery
- Cardiac surgery
- Extra-corporeal membrane oxygenation
- Organ transplantation
- Obstetric procedures
- Procedures on the kidney
- Outpatient procedures
- Already receiving NE or PE or inotropes before induction of anesthesia (at the time of anesthesia start)
- American Society of Anesthesiologists physical status classification 5 or 6
- Patient for whom a local protocol recommends a specific first line vasopressor
- Most recent documented estimated glomerular filtration rate (eGFR) \< 15 mL/min/1.73m\^2 or preoperative renal replacement therapy within 60 days before surgery
- Patients who do not have a preoperative creatinine value within 60 days before surgery
- Alive patients who do not have a postoperative creatinine value
The study team makes the final eligibility decision.
Where it's taking place
- San Francisco, California, United States
- College Park, Maryland, United States
- Ann Arbor, Michigan, United States
- Detroit, Michigan, United States
- Durham, North Carolina, United States
- Winston-Salem, North Carolina, United States
- Dallas, Texas, United States
- Charlottesville, Virginia, United States
- Seattle, Washington, United States
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include San Francisco, California, United States; College Park, Maryland, United States; Ann Arbor, Michigan, United States; Detroit, Michigan, United States; Durham, North Carolina, United States; Winston-Salem, North Carolina, United States and 4 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.