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New treatment option for Pain, Chronic
Official title Pain Reprocessing Therapy in Post-Operative Knee Pain
ClinicalTrials.gov ID: NCT06800209
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients are deemed eligible at 3 months post-operatively if: The patient completed a primary knee replacement [surgery completed without...
- Reported pre-operative chronic knee pain of at least 6 months duration prior to surgery
- The procedure was a primary (not a revision) knee replacement
- Proficient in English
You likely can't join if
- Patients who are not willing to participate in a telehealth visit.
- Patients with pre-op chronic pain but who do not have post-operative pain after the three month time period.
- Active suicidal ideation with intent, recent history of suicide attempt, or self-harm behaviors within the past 5 years (including non-suicidal...
- Recent history of inpatient psychiatric hospitalization within the past 5 years.
- Active, current psychosis or mania.
- Active, current substance abuse, or problems with substance abuse within the past 2 years.
See the full eligibility criteria
- Patients are deemed eligible at 3 months post-operatively if: The patient completed a primary knee replacement [surgery completed without complication and patient exhibits full mechanical joint function, as determined...
- Reported pre-operative chronic knee pain of at least 6 months duration prior to surgery
- The procedure was a primary (not a revision) knee replacement
- Proficient in English
- Patients who are not willing to participate in a telehealth visit.
- Patients with pre-op chronic pain but who do not have post-operative pain after the three month time period.
- Active suicidal ideation with intent, recent history of suicide attempt, or self-harm behaviors within the past 5 years (including non-suicidal self-harm).
- Recent history of inpatient psychiatric hospitalization within the past 5 years.
- Active, current psychosis or mania.
- Active, current substance abuse, or problems with substance abuse within the past 2 years.
- Instability in living conditions or major interfering life events:
- Major surgery or other major medical event planned in coming 6 months.
- Uncertain whether they will have suitable conditions for telehealth appointments over the next 2 months, including access to a computer or tablet, reliable high-speed internet, and a quiet, comfortable room that is...
- Major, interfering changes in employment or housing anticipated over the next 6 months.
- Neurological conditions (e.g., Alzheimer's, dementia, mild cognitive impairment, Huntington's disease, multiple sclerosis, cerebral palsy). This will be case-by-case decision made by PI to determine if the condition may...
- Self-reported diagnosis of an autoimmune disease (e.g., rheumatoid arthritis, polymyalgia rheumatica, scleroderma, lupus, polymyositis, or another autoimmune disorder).
- Currently or plan to be involved in lawsuits related to pain in next 6 months, currently or plan to apply for any disability payments related to the pain in next 6 months, or received legal settlement or other...
- Are unable or uncomfortable with completing a dry cap EEG.
- Has had a history of abnormal EEGs.
- Had bilateral TKA
The study team makes the final eligibility decision.
Where it's taking place
- Aurora, Colorado, United States
- New York, New York, United States
Compensation & support
Compensation likely.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Aurora, Colorado, United States; New York, New York, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.