BridgeMD
New treatment option for Diminished Ovarian Reserve
Official title The Effect of VitC on IVF Outcome of DOR Patients
ClinicalTrials.gov ID: NCT06794047
What this study is testing
- What it's testing
- In the context of the accelerating aging population and the continuous decline in birth rates nationwide, delaying reproductive aging in women and protecting the fertility of women of childbearing age have become urgent issues and key demands that need to be addressed in the field of maternal and child health in China. The ovaries have reproductive and hormone secretion functions and are crucial throughout the female reproductive lifecycle.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 20 to 45, women only
You may be able to join if
- Definition of DOR: Currently, there is no internationally unified standard for DOR. According to the latest POSEIDON criteria for diminished ovarian...
- Infertile women undergoing their 1st or 2nd IVF treatment
- Diagnosed with DOR: POSEIDON criteria (AMH \<1.2 ng/mL or bilateral AFC \<5) BMI between 18.5-28.0 kg/m²
- Signed informed consent
You likely can't join if
- ：Participants meeting any of the following criteria will be excluded from the trial:
- PGT (preimplantation genetic testing) candidates
- DOR caused by ovarian surgery, cancer radiotherapy/chemotherapy
- Other ovulation disorders (e.g., PCOS, Cushing's syndrome, non-classic congenital adrenal hyperplasia, hyperprolactinemia) or endometriosis...
- Severe thyroid disorders: Hyperthyroidism, Graves' disease, Hashimoto's thyroiditis
- Acute/chronic renal insufficiency, hemodialysis, or history of severe kidney impairment
See the full eligibility criteria
- Definition of DOR: Currently, there is no internationally unified standard for DOR. According to the latest POSEIDON criteria for diminished ovarian reserve (DOR), serum AMH \<1.20 ng/mL or bilateral antral follicle...
- Infertile women undergoing their 1st or 2nd IVF treatment
- Diagnosed with DOR: POSEIDON criteria (AMH \<1.2 ng/mL or bilateral AFC \<5) BMI between 18.5-28.0 kg/m²
- Signed informed consent
- ：Participants meeting any of the following criteria will be excluded from the trial:
- PGT (preimplantation genetic testing) candidates
- DOR caused by ovarian surgery, cancer radiotherapy/chemotherapy
- Other ovulation disorders (e.g., PCOS, Cushing's syndrome, non-classic congenital adrenal hyperplasia, hyperprolactinemia) or endometriosis (chocolate cysts)
- Severe thyroid disorders: Hyperthyroidism, Graves' disease, Hashimoto's thyroiditis
- Acute/chronic renal insufficiency, hemodialysis, or history of severe kidney impairment
- Infectious diseases: HIV, active hepatitis, metabolic acidosis, tuberculosis, etc.
- Severe autoimmune diseases (e.g., rheumatoid arthritis, lupus, Crohn's disease)
- Cardiovascular events within the past 3 months: Coronary artery disease/myocardial infarction/clinically significant congestive heart failure；Stroke/transient ischemic attack (TIA)；Deep vein thrombosis/pulmonary...
- Neurological disorders (e.g., dementia,Alzheimer's, Parkinson's) or use of related medications
- Psychiatric disorders or use of antiepileptic/antidepressant drugs
- History of cancer or radiotherapy/chemotherapy
- Allergy to vitamin C
- Current high-dose vitamin C supplementation (\>500 mg/day)
- Unwillingness to take the study-provided supplements
- Alcohol abuse, smoking, or drug addiction
- Participation in other clinical trials within the past month
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, Beijing Municipality, China
- Shijiazhuang, Hebei, China
- Yinchuan, Ningxia, China
- Xi’an, Shanxi, China
- Shenzhen, Shenzhen, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 20 years to 45 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, Beijing Municipality, China; Shijiazhuang, Hebei, China; Yinchuan, Ningxia, China; Xi’an, Shanxi, China; Shenzhen, Shenzhen, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.