BridgeMD
New treatment option for ARDS (Acute Respiratory Distress Syndrome)
Official title Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
ClinicalTrials.gov ID: NCT06790875
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn how low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV) affect lung tissue mechanics in adults with ARDS. The main questions it aims to answer are: Does LTV or APRV improve lung tissue mechanics in patients with ARDS under mechanical ventilation?
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Meets the diagnostic criteria of the 2023 Global New Definition of ARDS.
- Age: 18-80 years.
- PaO2/FiO2 ≤ 200.
- Within 12 hours of invasive mechanical ventilation treatment.
- Obtain consent from the patient or their family members to participate in the study, and sign the informed consent form.
You likely can't join if
- Age \ 80 years.
- Uncorrected shock of any type.
- Chronic obstructive pulmonary disease (COPD), pulmonary embolism, right heart failure, pulmonary hypertension, or severe arrhythmia.
- Contraindications for using Electrical Impedance Tomography (EIT) (extensive chest skin damage, infection, pacemaker implantation, implanted...
- Pregnant or breastfeeding women.
- Patients planned for ECMO treatment.
See the full eligibility criteria
- Meets the diagnostic criteria of the 2023 Global New Definition of ARDS.
- Age: 18-80 years.
- PaO2/FiO2 ≤ 200.
- Within 12 hours of invasive mechanical ventilation treatment.
- Obtain consent from the patient or their family members to participate in the study, and sign the informed consent form.
- Age \ 80 years.
- Uncorrected shock of any type.
- Chronic obstructive pulmonary disease (COPD), pulmonary embolism, right heart failure, pulmonary hypertension, or severe arrhythmia.
- Contraindications for using Electrical Impedance Tomography (EIT) (extensive chest skin damage, infection, pacemaker implantation, implanted automatic defibrillator, etc.), pneumothorax, mediastinal emphysema, or large...
- Pregnant or breastfeeding women.
- Patients planned for ECMO treatment.
- Patients currently participating in or previously enrolled in other clinical studies.
The study team makes the final eligibility decision.
Where it's taking place
- Wuhan, Hubei, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Wuhan, Hubei, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.