BridgeMD
Compares treatment options for Postoperative Delirium (POD)
Official title Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
ClinicalTrials.gov ID: NCT06788743
What this study is testing
What is TIVA ( anesthesia with propofol and remifentanil)?
TIVA ( anesthesia with propofol and remifentanil) is an investigational medicine, being studied as a potential treatment for postoperative delirium (pod).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The present study is a multicenter， randomized controlled clinical trial, which plans to enroll 450 diabetic patients aged more than 60 years. The participants will be randomly assigned in a 1:1 ratio and will receive either propofol or sevoflurane for intraoperative anesthesia maintenance to evaluate the impact of these two anesthetic drugs on postoperative delirium.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 60 and older
You may be able to join if
- Age ≥60 years
- Elective surgery (with an expected duration of 2 hours or more)
- ASA grade Ⅰ-Ⅲ
- Voluntary participation and informed consent obtained
- Diabetes mellitus
You likely can't join if
- Pre-operative BMI≥35 kg/m² (Class II obesity or above)
- Severe hepatic dysfunction (Child-Pugh class C) or pre-operative dialysis-dependent renal dysfunction
- Known neurological or psychiatric diseases (Parkinson's disease, depression, schizophrenia), or cognitive impairment (dementia)
- Severe visual or auditory impairments, language barriers, or patients who cannot cooperate
- Long-term use of sedatives, antipsychotic drugs, or long-term alcohol abuse
- Neurosurgical patients
See the full eligibility criteria
- Age ≥60 years
- Elective surgery (with an expected duration of 2 hours or more)
- ASA grade Ⅰ-Ⅲ
- Voluntary participation and informed consent obtained
- Diabetes mellitus
- Pre-operative BMI≥35 kg/m² (Class II obesity or above)
- Severe hepatic dysfunction (Child-Pugh class C) or pre-operative dialysis-dependent renal dysfunction
- Known neurological or psychiatric diseases (Parkinson's disease, depression, schizophrenia), or cognitive impairment (dementia)
- Severe visual or auditory impairments, language barriers, or patients who cannot cooperate
- Long-term use of sedatives, antipsychotic drugs, or long-term alcohol abuse
- Neurosurgical patients
- Patients with a known allergy to the drugs used in this study or those suspected of having propofol infusion syndrome
The study team makes the final eligibility decision.
Where it's taking place
- Xi’an, Shanxi, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 60 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Xi’an, Shanxi, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.