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New treatment option for Aging
Official title Examining the Effects of Theta Burst TMS on Brain Connectivity and Balance Ability in Older Adults With Balance Problems
ClinicalTrials.gov ID: NCT06779188
What this study is testing
- What it's testing
- The goal of this study is to learn if manipulating the brain using magnets works to treat balance impairment, a major cause of falls, in older adults with balance problems. The technique to manipulate the brain using magnets is known as transcranial magnetic stimulation or TMS.
- Phase 1: an early, usually small safety study
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 and older
You may be able to join if
- a) Able to provide informed consent b) All ethnic groups c) \>65 years of age d) ≥2 non-injury falls or ≥1 injury fall in the past year [17]-[21] e)...
- i) Willingness to undergo MRI, participate in the 4-weeks intervention AND in the laboratory studies before, immediately-after, and 3-month after the...
You likely can't join if
- Inability to provide informed consent.
- Non-English speaking.
- Have contraindications to TMS based on TMS Adult Safety Screen (e.g., pregnancy, metal in the brain/skull, neurostimulator, pacemaker, infusion...
- Unintentional weight loss of ≥10 pounds over the past year.
- Severe uncontrolled hypertension, or uncontrolled diabetes.
- Poor cognitive status (Montreal Cognitive Assessment (MoCA) score ≥ 26)
See the full eligibility criteria
- a) Able to provide informed consent b) All ethnic groups c) \>65 years of age d) ≥2 non-injury falls or ≥1 injury fall in the past year [17]-[21] e) Absence of dementia/uncontrolled psychiatric disorder h) Able to walk...
- i) Willingness to undergo MRI, participate in the 4-weeks intervention AND in the laboratory studies before, immediately-after, and 3-month after the intervention.
- Inability to provide informed consent.
- Non-English speaking.
- Have contraindications to TMS based on TMS Adult Safety Screen (e.g., pregnancy, metal in the brain/skull, neurostimulator, pacemaker, infusion device, medication to treat mental illness)
- Unintentional weight loss of ≥10 pounds over the past year.
- Severe uncontrolled hypertension, or uncontrolled diabetes.
- Poor cognitive status (Montreal Cognitive Assessment (MoCA) score ≥ 26)
- Untreated depression or Geriatric Depression Scale score on 15 item scale \>7
- History of limb amputation (upper or lower extremity)
- Planned surgery in the next 3 months.
- History of chemotherapy or planned chemotherapy in the next 6 months or active malignancy.
- Severe osteoporosis, defined by diagnosis of osteoporosis with fracture.
- Pregnant or have a chance of being pregnant.
- Chronic inflammatory condition, autoimmune disease or infectious processes such as active tuberculosis, Human Immunodeficiency Virus, Rheumatoid arthritis, systemic lupus erythematosus, acute or chronic hepatitis B or C.
- Illicit drug use
- Use of medications that may increase the risk of falling:
- Sedatives
- Hypnotics
- Anti-cholinergic
- Benzodiazepines
- Anti-depressants
- Intracranial bleeds visible on their most recent CT or MRI scans.
The study team makes the final eligibility decision.
Where it's taking place
- Houston, Texas, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Houston, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.