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New treatment option for Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Official title Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
ClinicalTrials.gov ID: NCT06776042
What this study is testing
- What it's testing
- The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). The main questions it aims to answer are: Is the type 2 inflammation impacting the olfactory epithelium regeneration, leading to OD?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70. Healthy volunteers may be eligible.
You may be able to join if
- At least two of the following symptoms: nasal obstruction, rhinorrhoea, smell loss, facial pain for 12 weeks.
- Endoscopic visualisation of bilateral sinonasal polyps
- SSI (TDI) \< 30.75 and decreased sense of smell subjectively
- Eosinophilia \> 300/μl of blood Ku/l
- On a stable nasal steroid treatment for at least 4 weeks
You likely can't join if
- Active smoking
- Primary and secondary immune deficiencies
- Ciliary diseases (cystic fibrosis, primary ciliary diskinesia)
- History of or current nasal malignancies
- \ 70 years
- Patients unable to express consent
See the full eligibility criteria
- At least two of the following symptoms: nasal obstruction, rhinorrhoea, smell loss, facial pain for 12 weeks.
- Endoscopic visualisation of bilateral sinonasal polyps
- SSI (TDI) \< 30.75 and decreased sense of smell subjectively
- Eosinophilia \> 300/μl of blood Ku/l
- On a stable nasal steroid treatment for at least 4 weeks
- Active smoking
- Primary and secondary immune deficiencies
- Ciliary diseases (cystic fibrosis, primary ciliary diskinesia)
- History of or current nasal malignancies
- \ 70 years
- Patients unable to express consent
- Use of systemic corticosteroids for \< 4 weeks before visit 1 Use of systemic or local antibiotics for \< 4 weeks before visit 1
The study team makes the final eligibility decision.
Where it's taking place
- Brussels, Belgium
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Brussels, Belgium. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.