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Compares treatment options for Pain, Postoperative
Official title Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.
ClinicalTrials.gov ID: NCT06774274
What this study is testing
What is Ketamine infusion?
Ketamine infusion is an investigational medicine, given as an once-daily infusion into a vein, being studied as a potential treatment for pain, postoperative.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to determine whether treating pain after surgery with ketamine is more effective when administered intravenously as a continuous infusion or through a patient-controlled analgesia (PCA) pump. This study focuses on adult volunteers following major orthopedic surgery.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Patients over 18 years of age
- Elective major orthopedic surgery.
- ASA (American Association of Anesthesiology) classification 1, 2 or 3.
You likely can't join if
- Patients with a diagnosis of perioperative kidney injury or hepatic failure
- Patients with active cardiac conditions
- Patients with any cognitive impairment that disables the patient from operating the PCA pump or impedes the postoperative interview
- Patients with scheduled ICU admission with invasive ventilatory support
- Patients with known hypersensitivity to opioid medications
- Patients with past medical history of severe adverse reactions to opioids or ketamine.
See the full eligibility criteria
- Patients over 18 years of age
- Elective major orthopedic surgery.
- ASA (American Association of Anesthesiology) classification 1, 2 or 3.
- Patients with a diagnosis of perioperative kidney injury or hepatic failure
- Patients with active cardiac conditions
- Patients with any cognitive impairment that disables the patient from operating the PCA pump or impedes the postoperative interview
- Patients with scheduled ICU admission with invasive ventilatory support
- Patients with known hypersensitivity to opioid medications
- Patients with past medical history of severe adverse reactions to opioids or ketamine.
- Pregnant patients
- Patients undergoing continuous regional anesthetic techniques including peripheral nerve catheters or continuous epidural catheters
- Patient refusal to participate in the study
The study team makes the final eligibility decision.
Where it's taking place
- Medellín, Antioquia, Colombia
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Medellín, Antioquia, Colombia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.