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New treatment option for Suspected Stroke
Official title Early Initiated Ambulance-delivered Levetiracetam and Headposition in Hyper-acute Stroke Trial
ClinicalTrials.gov ID: NCT06773364
What this study is testing
What is Levetiracetam?
Levetiracetam is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for suspected stroke.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is an investigator initiated and conducted, multicentre, ambulance-delivered, prospective, randomised, open-label, blinded outcome (PROBE) study. EAST aims to evaluate the effects of pre-hospital levetiracetam and different head positions initiated in ambulance settings on the functional outcome of participants assessed at 90 days.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adults (age ≥18 years);
- Acute condition that is presumed due to acute stroke, defined on the FAST (Face, Arm, Speech, Time) screen (score ≥2 with an arm deficit);
- Time ≤2 hours from last seen well;
- Able to provide brief consent (if a waver of consent not approved by ethics committee).
You likely can't join if
- coma (no response to painful stimulation);
- severe co-morbid disease (e.g. cancer, chronic airflow disease, severe dementia, severe heart failure, pre-existing disability [needing help with...
- history of epilepsy or seizure at onset;
- recent head injury;
- hypoglycaemia (glucose \<2.8mmol/L);
- clear indications or contraindications (allergies) for levetiracetam;
See the full eligibility criteria
- Adults (age ≥18 years);
- Acute condition that is presumed due to acute stroke, defined on the FAST (Face, Arm, Speech, Time) screen (score ≥2 with an arm deficit);
- Time ≤2 hours from last seen well;
- Able to provide brief consent (if a waver of consent not approved by ethics committee).
- coma (no response to painful stimulation);
- severe co-morbid disease (e.g. cancer, chronic airflow disease, severe dementia, severe heart failure, pre-existing disability [needing help with everyday activities]);
- history of epilepsy or seizure at onset;
- recent head injury;
- hypoglycaemia (glucose \<2.8mmol/L);
- clear indications or contraindications (allergies) for levetiracetam;
- lactating women;
- clear indications for a particular head position or situations where either head position cannot be maintained (such as severe vomiting and inability to lie down, severe obesity with fatigue and difficulty sitting up...
The study team makes the final eligibility decision.
Where it's taking place
- Suzhou, Anhui, China
- Shanghai, Shanghai Municipality, China
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Suzhou, Anhui, China; Shanghai, Shanghai Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.