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Tests treatment safety and results for SIBO
Official title Efficacy of Rifaximin in Patients With Small Intestinal Bacterial Overgrowth Presenting With Abdominal Bloating.
ClinicalTrials.gov ID: NCT06772064
What this study is testing
What is Rifaximin (drug)?
Rifaximin (drug) is an investigational medicine, given as a twice-daily pill taken by mouth, being studied as a potential treatment for sibo.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Abdominal bloating is a common clinical symptom in the digestive system, with obscure origins and complex mechanisms. Its etiology can be attributed to organic diseases and various Functional Gastrointestinal Disorders (FGIDs).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70. Healthy volunteers may be eligible.
You may be able to join if
- Healthy Group
- Age between 18 and 70 years, both genders included.
- No special gastrointestinal discomfort such as bloating or abdominal pain, regular bowel movements, and normal stool characteristics.
- Negative hydrogen/methane breath test.
You likely can't join if
- Pregnant or lactating women.
- History of gastrointestinal malignancy or gastrointestinal surgery.
- Past diagnosis or suspicion of lactose intolerance.
- Confirmed extra-digestive system diseases such as urinary system (chronic kidney disease, etc.), immune system (scleroderma, etc.), nervous system...
- Abnormalities in professional anxiety and depression symptom rating scales.
- Use of antibiotics, probiotics within two weeks, endoscopic examination, or use of prokinetics, secretagogues, antifoaming agents, antispasmodics...
See the full eligibility criteria
- Healthy Group
- Age between 18 and 70 years, both genders included.
- No special gastrointestinal discomfort such as bloating or abdominal pain, regular bowel movements, and normal stool characteristics.
- Negative hydrogen/methane breath test.
- Pregnant or lactating women.
- History of gastrointestinal malignancy or gastrointestinal surgery.
- Past diagnosis or suspicion of lactose intolerance.
- Confirmed extra-digestive system diseases such as urinary system (chronic kidney disease, etc.), immune system (scleroderma, etc.), nervous system (Parkinson's, etc.), endocrine system (diabetes, etc.).
- Abnormalities in professional anxiety and depression symptom rating scales.
- Use of antibiotics, probiotics within two weeks, endoscopic examination, or use of prokinetics, secretagogues, antifoaming agents, antispasmodics, opioids, antidepressants within one week.
- Those who cannot or are unwilling to sign an informed consent form. Patient Group: Inclusion Criteria:
- Age between 18 and 70 years, both genders included.
- Chief complaints of abdominal bloating and/or distension; outpatients with abdominal bloating and/or distension more prominent than other symptoms.
- Positive hydrogen/methane breath test. Exclusion Criteria:
- Pregnant or lactating women.
- History of gastrointestinal malignancy or gastrointestinal surgery.
- Past diagnosis or suspicion of lactose intolerance.
- Confirmed extra-digestive system diseases such as urinary system (chronic kidney disease, etc.), immune system (scleroderma, etc.), nervous system (Parkinson's, etc.), endocrine system (diabetes, etc.).
- Moderate to severe abnormalities in professional anxiety and depression symptom rating scales.
- Use of antibiotics, probiotics within two weeks, endoscopic examination, or use of prokinetics, secretagogues, antifoaming agents, antispasmodics, opioids, antidepressants within one week.
- Those who cannot or are unwilling to sign an informed consent form.
The study team makes the final eligibility decision.
Where it's taking place
- Jinan, Shandong, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Jinan, Shandong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.