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New treatment option for Cardiac Surgery-associated Acute Kidney Injury
Official title A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine
ClinicalTrials.gov ID: NCT06772025
What this study is testing
- What it's testing
- Researchers are looking for a better way to treat and prevent cardiac surgery-associated acute kidney injury (CSA-AKI) in people who undergo heart surgeries. CSA-AKI is a common complication in people undergoing heart surgeries, where the kidneys stop working properly.
- Time commitment: about 2 months
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Participant must be at least 18 years of age at the time of signing the informed consent form (ICF).
- Participants who are scheduled for hospital admission for any of the following cardiovascular surgery interventions, alone or in combination...
- Aortic, mitral, or tricuspid valve surgery (repair or replacement)
- Aortic surgery
- ≥3 coronary artery bypass grafts
You likely can't join if
- Emergency surgery situation
- Anemia - hemoglobin \<10 g/dL
- Clinical signs of systemic infection or other infection requiring anti-infective treatment (viral, bacterial, fungal, parasitic; single-dose...
- Systemic immunosuppressive or anti-inflammatory treatment including corticosteroids \>10 mg prednisolone equivalent/day
- Any anti-cancer treatment within 3 months (e.g. immunotherapy, chemotherapy, radiotherapy)
- Major surgery within 2 months
See the full eligibility criteria
- Participant must be at least 18 years of age at the time of signing the informed consent form (ICF).
- Participants who are scheduled for hospital admission for any of the following cardiovascular surgery interventions, alone or in combination, involving cardiopulmonary bypass (CPB):
- Aortic, mitral, or tricuspid valve surgery (repair or replacement)
- Aortic surgery
- ≥3 coronary artery bypass grafts
- Participant with: chronic kidney disease (CKD): 30 ≤ estimated glomerular filtration rate (eGFR) \< 90 mL/min/1.73 m\^2
- Emergency surgery situation
- Anemia - hemoglobin \<10 g/dL
- Clinical signs of systemic infection or other infection requiring anti-infective treatment (viral, bacterial, fungal, parasitic; single-dose prophylaxis allowed)
- Systemic immunosuppressive or anti-inflammatory treatment including corticosteroids \>10 mg prednisolone equivalent/day
- Any anti-cancer treatment within 3 months (e.g. immunotherapy, chemotherapy, radiotherapy)
- Major surgery within 2 months
- AKI within the last month
- Prior renal transplants or RRT
- Planned use of contrast media within 5 days prior to surgery or during surgery
- Patient included in an treatment clinical trial involving a pharmacological intervention
- Any reason that would make participation unadvisable, at the discretion of the investigator.
- Autoimmune disorders such as anti-glomerular basement membrane (anti-GBM) diseases, systemic lupus erythematosus, chronic rheumatic heart diseases, acute rheumatic heart pericarditis, endocarditis, myocarditis...
The study team makes the final eligibility decision.
Where it's taking place
- Bad Oeynhausen, North Rhine-Westphalia, Germany
- Cambridge, Cambridgeshire, United Kingdom
- Harefield, Greater London, United Kingdom
- London, Greater London, United Kingdom
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 2 months per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bad Oeynhausen, North Rhine-Westphalia, Germany; Cambridge, Cambridgeshire, United Kingdom; Harefield, Greater London, United Kingdom; London, Greater London, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.