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Official title Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI
ClinicalTrials.gov ID: NCT06763172
What this study is testing
What is Caffeine (200 mg)?
Caffeine (200 mg) is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for healthy.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This research study aims to determine whether and how caffeine intake affects learning process through reward feedback compared to placebo. The data acquired from this study would improve our understanding on the consequence and mechanism of caffeine intake in the aspect of learning process.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 45. Healthy volunteers may be eligible.
You may be able to join if
- Age ≥ 18 and ≤ 45.
- Habitual caffeine intake ≥ 100 mg and ≤ 450 mg daily.
- Non-smokers.
- Clinically healthy.
- Have normal vision or corrected to normal vision.
You likely can't join if
- Pregnant or lactating women.
- Women using hormonal contraceptives.
- BMI \ 29.9
- Sleep disturbance or extreme chronotype.
- Urine test positive on one of the following substances: benzoylecgonine, morphine, d-Methamphetamine, d-Amphetamine, Benzodiazepines, Secobarbital...
- Diagnosis of depression, anxiety, psychosis, or neurologic disorders in the last 5 years.
See the full eligibility criteria
- Age ≥ 18 and ≤ 45.
- Habitual caffeine intake ≥ 100 mg and ≤ 450 mg daily.
- Non-smokers.
- Clinically healthy.
- Have normal vision or corrected to normal vision.
- Pregnant or lactating women.
- Women using hormonal contraceptives.
- BMI \ 29.9
- Sleep disturbance or extreme chronotype.
- Urine test positive on one of the following substances: benzoylecgonine, morphine, d-Methamphetamine, d-Amphetamine, Benzodiazepines, Secobarbital, Methadone, Buprenorphine Glucuronide, Nortriptyline, MDMA, Oxycodone...
- Diagnosis of depression, anxiety, psychosis, or neurologic disorders in the last 5 years.
- Heart or cardiovascular diseases.
- Diabetes or other metabolic diseases.
- Under chronic medications, for instance, painkiller and steroid.
- Allergy to lactose (main ingredient of blank control dose)
- Incapable to operate the tasks or comprehend the study information in English. General MRI and PET safety exclusion criteria for all people:
- Metallic foreign bodies such as cardiac pacemakers, perfusion pumps, aneurysm clips, metallic tattoos anywhere on the body, tattoos near the eye.
- Pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions
- Inability to lie flat on scanner bed for about 90 min as assessed by physical examination and medical history (e.g. arthritis)
- Recent exposure to radiation (i.e., PET from other research studies) that, when combined with this study, would be above the allowable limits
- Pregnancy or breastfeeding: A negative serum or urine pregnancy test is required on the day of the PET procedure
- Body weight of \> 300 lbs (weight limit of the MRI scanner table)
The study team makes the final eligibility decision.
Where it's taking place
- Charlestown, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 45 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Charlestown, Massachusetts, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.