BridgeMD
New treatment option for Dental Plaque
Official title Probiotic Treatment of Orthodontic Patients
ClinicalTrials.gov ID: NCT06751979
What this study is testing
- What it's testing
- The purpose of this study is to examine the effect of treatment with a lozenge containing the probiotic strain S. salivarius M18 on the formation, composition and virulence of dental plaque and in healthy orthodontic patients, compared to placebo control.
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 10 and older. Healthy volunteers may be eligible.
You may be able to join if
- Generally healthy males and females ≥ 10 years of age.
- Able to read and receive a copy of the signed informed consent form.
- Have at least 20 natural teeth.
- Have been undergoing orthodontic treatment with fixed orthodontic appliances in the upper and/or lower jaw \> 6 months.
- An average plaque score of \> 2 according to the Modified Orthodontic Plaque Index (MOPI) at the screening appointment.
You likely can't join if
- Significant oral soft tissue pathology based on a visual examination.
- History of allergy or significant adverse events following use of oral hygiene products such as toothpastes, mouth rinses, breath mints, lozenges, or...
- History of allergies to milk proteins.
- History of allergies towards probiotics.
- Self-reported as pregnant or nursing.
- Self-reported serious medical conditions.
See the full eligibility criteria
- Generally healthy males and females ≥ 10 years of age.
- Able to read and receive a copy of the signed informed consent form.
- Have at least 20 natural teeth.
- Have been undergoing orthodontic treatment with fixed orthodontic appliances in the upper and/or lower jaw \> 6 months.
- An average plaque score of \> 2 according to the Modified Orthodontic Plaque Index (MOPI) at the screening appointment.
- Significant oral soft tissue pathology based on a visual examination.
- History of allergy or significant adverse events following use of oral hygiene products such as toothpastes, mouth rinses, breath mints, lozenges, or chewing gum or their ingredients.
- History of allergies to milk proteins.
- History of allergies towards probiotics.
- Self-reported as pregnant or nursing.
- Self-reported serious medical conditions.
- Antibiotic or anti-inflammatory medication within 30 days of screening visit.
- Acute sinusitis or severe oral-pharyngeal infections.
- Smoker.
The study team makes the final eligibility decision.
Where it's taking place
- Aarhus, Denmark
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 10 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Aarhus, Denmark. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.