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Compares treatment options for Chronic Rhinosinusitis (CRS)
Official title Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical Trial
ClinicalTrials.gov ID: NCT06750302
What this study is testing
What is Methoxyflurane - Penthrox?
Methoxyflurane - Penthrox is an investigational medicine, given as an inhaled treatment, being studied as a potential treatment for chronic rhinosinusitis (crs).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this randomized controlled trial is to evaluate the effectiveness of inhaled methoxyflurane (Penthrox) as an analgesic for patients undergoing minor rhinology and sinus procedures, specifically comparing it to a placebo control. The primary question the study aims to answer is: Does methoxyflurane provide superior pain relief compared to placebo during minor sinus procedures, as measured by the Visual Analog Scale (VAS)?
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 19 and older
You may be able to join if
- Age 19 years or older
- Scheduled for minor sinus surgery or coblation procedures
You likely can't join if
- Cystic fibrosis
- Systemic vasculitis or other bleeding disorders
- History of renal failure or severe kidney disease
- History of liver failure or severe liver disease
- Altered state of consciousness (head injury, alcohol use, drug use)
- Known or suspected hypersensitivity to lidocaine or sensorcaine
See the full eligibility criteria
- Age 19 years or older
- Scheduled for minor sinus surgery or coblation procedures
- Cystic fibrosis
- Systemic vasculitis or other bleeding disorders
- History of renal failure or severe kidney disease
- History of liver failure or severe liver disease
- Altered state of consciousness (head injury, alcohol use, drug use)
- Known or suspected hypersensitivity to lidocaine or sensorcaine
- Inhaled drug use (i.e., cocaine) in the preceding 6 months
- Nasal tumors
- Personal or family history of malignant hyperthermia
- Respiratory depression
The study team makes the final eligibility decision.
Where it's taking place
- Vancouver, British Columbia, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 19 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Vancouver, British Columbia, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.