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Official title Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux
ClinicalTrials.gov ID: NCT06746623
What this study is testing
- What it's testing
- The veteran population is at increased risk for EAC and its precursor lesion, Barrett's esophagus (BE), due to increased prevalence of disease risk factors compared to the general population. BE is traditionally diagnosed only when patients undergo endoscopy with biopsies.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 85
You may be able to join if
- Patients without history of chronic GERD who meet criteria for upper endoscopic screening for BE will be accrued35.
- Adults \> 40 and \< 85 years old who have no prior EGD and can provide informed consent
- Absence of chronic GERD symptoms (absence of weekly heartburn or regurgitation, not on medications for GERD), and are: a. Meet ACG/AGA Clinical...
- No known coagulopathy, no known esophageal varices, not on chronic anticoagulation therapy, and have:
- No significant dysphagia or odynophagia
You likely can't join if
- Exclusion Criteria
- History of prior EGD procedure in past ten years
- Inability to provide written informed consent
- History of weekly or more frequent heartburn or regurgitation for five or more years
- On anti-coagulant drug(s) that cannot be temporarily discontinued or coagulopathy with INR \> 1.5
- Known history of esophageal varices or esophageal stricture
See the full eligibility criteria
- Patients without history of chronic GERD who meet criteria for upper endoscopic screening for BE will be accrued35.
- Adults \> 40 and \< 85 years old who have no prior EGD and can provide informed consent
- Absence of chronic GERD symptoms (absence of weekly heartburn or regurgitation, not on medications for GERD), and are: a. Meet ACG/AGA Clinical Guideline criteria for BE screening. Eligible people will have at least...
- No known coagulopathy, no known esophageal varices, not on chronic anticoagulation therapy, and have:
- No significant dysphagia or odynophagia
- Exclusion Criteria
- History of prior EGD procedure in past ten years
- Inability to provide written informed consent
- History of weekly or more frequent heartburn or regurgitation for five or more years
- On anti-coagulant drug(s) that cannot be temporarily discontinued or coagulopathy with INR \> 1.5
- Known history of esophageal varices or esophageal stricture
- Any contraindication, as deemed in Investigator's medical judgment, to undergoing the EsoCheck procedure, undergoing the EGD procedure, and/or having biopsies taken, including but not limited to due to comorbidities...
- History of difficulty swallowing (dysphagia) or painful swallowing (odynophagia), including swallowing pills
- Oropharyngeal tumor
- History of esophageal or gastric surgery, with exception on uncomplicated recent surgical fundoplication procedure with documented normal acid exposure time (AET) percent (AET \<4%)
- History of myocardial infarction or cerebrovascular accident within past 6 months
The study team makes the final eligibility decision.
Where it's taking place
- Cleveland, Ohio, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Cleveland, Ohio, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.