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New treatment option for Schizophrenia
Official title Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study
ClinicalTrials.gov ID: NCT06745479
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn if attention and ways of thinking impact decision-making and brain processes related to decision-making in people with schizophrenia or schizoaffective disorder relative to people without either condition. It will also learn how brain functioning during decision-making relates to real-world decisions made during daily life.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 50. Healthy volunteers may be eligible.
You may be able to join if
- The following criteria apply to all people:
- Between ages of 18-50.
- Have capacity to provide informed consent
- Fluent communication in English
- Willingness and ability to follow study requirements, as evidenced by an ability to provide written or virtual informed consent and read, and...
You likely can't join if
- The following criteria apply to all people:
- Self-disclosed or noticeable intoxication from alcohol or illicit drugs (e.g., arriving to participate in the study drunk/high)
- Self-disclosure of consistent current substance use other than nicotine, alcohol, or cannabis (e.g. cocaine, heroin).
- Many-year history of severely disordered substance use other than nicotine/tobacco (determined via interview)
- Significant physical health disorder, robust physical health conditions, neurological disease/disorder (e.g., Parkinson's, history of strokes).
- History of traumatic brain injury, head injury resulting in loss of consciousness for an extended duration or with noted neurobehavioral consequences.
See the full eligibility criteria
- The following criteria apply to all people:
- Between ages of 18-50.
- Have capacity to provide informed consent
- Fluent communication in English
- Willingness and ability to follow study requirements, as evidenced by an ability to provide written or virtual informed consent and read, and complete, study procedures.
- Cognitive ability to understand tasks and estimated IQ greater than 70. The following criteria apply to people with schizophrenia: 1\. Primary diagnosis of schizophrenia or schizoaffective disorder The following...
- The following criteria apply to all people:
- Self-disclosed or noticeable intoxication from alcohol or illicit drugs (e.g., arriving to participate in the study drunk/high)
- Self-disclosure of consistent current substance use other than nicotine, alcohol, or cannabis (e.g. cocaine, heroin).
- Many-year history of severely disordered substance use other than nicotine/tobacco (determined via interview)
- Significant physical health disorder, robust physical health conditions, neurological disease/disorder (e.g., Parkinson's, history of strokes).
- History of traumatic brain injury, head injury resulting in loss of consciousness for an extended duration or with noted neurobehavioral consequences.
- Electroconvulsive therapy within one month of participation.
- History of seizures or epilepsy.
- Currently untreated or unstable psychiatric and medical conditions.
- Intellectual disability
- Contra indications for MR imaging (detailed below) The following additional criteria apply to people without schizophrenia:
- Pervasive history of problematic substance use (other than nicotine, alcohol, and mild-moderate cannabis use) as defined by meeting DSM-5 criteria for a substance use disorder.
- Diagnosis of, or first-degree relative with, significant psychiatric disorder (e.g., bipolar disorder, psychotic disorder, or Cluster A personality disorder).
The study team makes the final eligibility decision.
Where it's taking place
- Piscataway, New Jersey, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 50 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Piscataway, New Jersey, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.