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New treatment option for Lynch Syndrome
Official title Video Capsule Examination in Patients With Lynch Syndrome
ClinicalTrials.gov ID: NCT06712095
What this study is testing
- What it's testing
- Surveillance for colorectal cancer (CRC) in patients predisposed to develop CRC during their lifetime has been impacted by access to colonoscopy suites and endoscopy specialists in the past couple of years. An alternative method, namely the colon capsule, has been proposed, however this investigation is time consuming for the clinician and the images require up to one hour (30-60 minutes) reading to issue a result.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Patients over the age of 18 years old with no active cancer
- No previous resection of the colon and/or rectum
- Carriers of a pathogenic/likely pathogenic variant in any of the following cancer-predisposition genes: Lynch syndrome (MLH1, MSH2, MSH6, PMS2), APC...
- Able to consent to the study and undergo colonoscopy.
You likely can't join if
- Extensive surgery which poses a high risk of video-capsule blockage or narrowing of the bowel due to extensive tumour. Extensive surgery implies any...
- Previous irradiation to abdomen or pelvis (risk for small bowel obstruction)
- Carriers of a variant associated with reduced penetrance (in the view of a geneticist) or a variant of uncertain significance.
- Patients with a PS of 3 or 4 and/or mobility issues
- Pregnancy
- Pacemaker or internal electro-medical device (artificial heart valve, cochlear implant or an internal electromedical device).
See the full eligibility criteria
- Patients over the age of 18 years old with no active cancer
- No previous resection of the colon and/or rectum
- Carriers of a pathogenic/likely pathogenic variant in any of the following cancer-predisposition genes: Lynch syndrome (MLH1, MSH2, MSH6, PMS2), APC (FAP syndrome); biallelic MUTYH; STK11 (Peutz-Jeghers syndrome); PTEN...
- Able to consent to the study and undergo colonoscopy.
- Extensive surgery which poses a high risk of video-capsule blockage or narrowing of the bowel due to extensive tumour. Extensive surgery implies any removal of large portions of the small or large bowel that might cause...
- Previous irradiation to abdomen or pelvis (risk for small bowel obstruction)
- Carriers of a variant associated with reduced penetrance (in the view of a geneticist) or a variant of uncertain significance.
- Patients with a PS of 3 or 4 and/or mobility issues
- Pregnancy
- Pacemaker or internal electro-medical device (artificial heart valve, cochlear implant or an internal electromedical device).
- Insulin-dependent diabetes
- Patients who require deep sedation for colonoscopy
The study team makes the final eligibility decision.
Where it's taking place
- London, (Select), United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include London, (Select), United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.