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New treatment option for Tumor
Official title Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）
ClinicalTrials.gov ID: NCT06711432
What this study is testing
What is Norepinephrine or phenylephrine?
Norepinephrine or phenylephrine is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for tumor.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a randomized controlled study to explore whether perioperative blood pressure management with different strategies can reduce the incidence of delirium and postoperative cognitive impairment and serious perfusion related complications (persistent hypotension, new heart arrhythmia, cardiac insufficiency, new stroke, sudden death, etc.) within 30 days after stroke in cancer patients at high risk for stroke. Patients were randomly divided into: 1) strict blood pressure management group: norepinephrine or phenylephrine maintenance intraoperative MAP≥85 mmHg, and 2) conventional blood pressure management group: intraoperative routine blood pressure management (MAP≥65mmHg).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 85
You may be able to join if
- Patients with high-risk stroke (combined with 3 risk factors or more according to the stroke risk screening table)
- Patients who plan to undergo surgery for abdominal tumors (gynecological, urinary, hepatobiliary, and gastrointestinal tumors) under general...
- The ASA is rated as Class II or III
- Patients who underwent invasive arterial blood pressure monitoring before surgery signed informed consent
You likely can't join if
- Patients do not want to participate in the study
- Patients with severe heart disease (severe valvular disease, sick sinus syndrome, high atrioventricular block without pacemaker implantation), grade...
- Need kidney replacement therapy; New stroke \<3 months
- Emergency surgery
- Preoperative history of mental illness, epilepsy, Parkinson's disease, or myasthenia gravis
- Speech, vision, or hearing impairment that prevents completion of a cognitive function assessment
See the full eligibility criteria
- Patients with high-risk stroke (combined with 3 risk factors or more according to the stroke risk screening table)
- Patients who plan to undergo surgery for abdominal tumors (gynecological, urinary, hepatobiliary, and gastrointestinal tumors) under general anesthesia are expected to have surgery duration \>2 hours
- The ASA is rated as Class II or III
- Patients who underwent invasive arterial blood pressure monitoring before surgery signed informed consent
- Patients do not want to participate in the study
- Patients with severe heart disease (severe valvular disease, sick sinus syndrome, high atrioventricular block without pacemaker implantation), grade III or above Liver function impairment (Child-Pugh class C)
- Need kidney replacement therapy; New stroke \<3 months
- Emergency surgery
- Preoperative history of mental illness, epilepsy, Parkinson's disease, or myasthenia gravis
- Speech, vision, or hearing impairment that prevents completion of a cognitive function assessment
- Situations where strict blood pressure management is not appropriate, such as controlled hypotension during surgery.
The study team makes the final eligibility decision.
Where it's taking place
- Hangzhou, Zhejiang, China
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hangzhou, Zhejiang, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.