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New treatment option for Chronic Non-Specific Low Back Pain
Official title The Effect of Intermittent Theta Burst Stimulation on Brain Characteristics, Pain Intensity, and Cognitive Functions in Older People with Chronic Musculoskeletal Pain.
ClinicalTrials.gov ID: NCT06709963
What this study is testing
- What it's testing
- The goal of this clinical trial is to explore the effects of accelerated intermittent Theta Burst Stimulation (iTBS) on pain relief and cognitive function in older adults with chronic musculoskeletal pain. It will also utilize magnetic resonance imaging to illustrate the neurophysiological mechanisms underlying the role of iTBS in improving various outcome indicators in this population.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 60 to 85
You may be able to join if
- have normal cognitive function (Hong Kong Montreal Cognitive Assessment ≥ 26)
- be right-handed
- be able to speak Cantonese
- chronic nonspecific low back pain, or having both chronic nonspecific low back pain and chronic knee pain that has lasted for at least 3 months
- an average pain intensity of ≥ 5 out of 10 on an 11-point numerical rating scale in the last 7 days, where 0 means "no pain" and 10 means "worst pain...
You likely can't join if
- inability to ambulate without assistance from another person (canes or walkers will be allowed);
- having specific causes of chronic nonspecific low back pain, or having both chronic nonspecific low back pain and chronic knee pain (e.g., spinal...
- having other concurrent musculoskeletal conditions at other body parts (e.g., fibromyalgia, or neck pain)
- self-reported history of lumbar or lower extremity surgery
- self-reported history of neurological or psychiatric disorders (e.g., stroke, brain surgery, head trauma; schizophrenia, multiple personality...
- self-reported specific inflammatory disorder: rheumatoid arthritis, rheumatica, scleroderma, lupus, or polymyositis
See the full eligibility criteria
- have normal cognitive function (Hong Kong Montreal Cognitive Assessment ≥ 26)
- be right-handed
- be able to speak Cantonese
- chronic nonspecific low back pain, or having both chronic nonspecific low back pain and chronic knee pain that has lasted for at least 3 months
- an average pain intensity of ≥ 5 out of 10 on an 11-point numerical rating scale in the last 7 days, where 0 means "no pain" and 10 means "worst pain imaginable"
- having pain at least half of the days in the past 4 weeks.
- have at least 6 years of formal education and know how to read and write Chinese
- agree to sign an informed consent and complete the experiment tests
- be able to communicate via email or text message, as several study measures will be collected electronically
- inability to ambulate without assistance from another person (canes or walkers will be allowed);
- having specific causes of chronic nonspecific low back pain, or having both chronic nonspecific low back pain and chronic knee pain (e.g., spinal stenosis, lumbar disc herniation, spondylolisthesis, recent vertebral...
- having other concurrent musculoskeletal conditions at other body parts (e.g., fibromyalgia, or neck pain)
- self-reported history of lumbar or lower extremity surgery
- self-reported history of neurological or psychiatric disorders (e.g., stroke, brain surgery, head trauma; schizophrenia, multiple personality disorder, dissociative identity disorder, stroke) or self-reported cancer...
- self-reported specific inflammatory disorder: rheumatoid arthritis, rheumatica, scleroderma, lupus, or polymyositis
- unexplained, unintended weight loss of 20 lbs or more in the past year
- cauda equina syndrome
- uncorrected visual deficit
- drug or alcohol addiction
- taken alcohol, opioids or benzodiazepines medicines 24 hours before the experiment
- claustrophobia
- contraindications for undergoing the magnetic resonance imaging (MRI) examination based on the MRI safety screening form of University Research Facility in Behavioral and Systems Neuroscience (UBSN) at The Hong Kong...
The study team makes the final eligibility decision.
Where it's taking place
- Hong Kong, Hong Kong
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 60 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hong Kong, Hong Kong. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.