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New treatment option for Nitric Oxide
Official title Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass
ClinicalTrials.gov ID: NCT06702553
What this study is testing
What is Nitric Oxide Gas?
Nitric Oxide Gas is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for nitric oxide.
Also referred to as Nitric Oxide inhalation.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Cardiac surgery is a procedure that is commonly performed worldwide. Despite these technological advances, cardiac surgery remains a high-risk surgery.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years.
- Elective cardiac or aortic surgery requiring CPB
- Without history of previous open heart surgery.
You likely can't join if
- Immediate emergency cardiac surgery;
- Cardiac surgery that requires deep hypothermic circulatory arrest;
- Planned cardiac surgery for congenital heart disease repair;
- Planned for heart transplatation
- Ongoing heart failure or low output syndrome already on intensive support (IABP, ECMO, left ventricular assist device such as impella, mechanical...
- Already accepted or currently on inhaled NO therapy or inhaled/aerosolized prostacyclin in the week prior to the enrollment;
See the full eligibility criteria
- Age ≥18 years.
- Elective cardiac or aortic surgery requiring CPB
- Without history of previous open heart surgery.
- Immediate emergency cardiac surgery;
- Cardiac surgery that requires deep hypothermic circulatory arrest;
- Planned cardiac surgery for congenital heart disease repair;
- Planned for heart transplatation
- Ongoing heart failure or low output syndrome already on intensive support (IABP, ECMO, left ventricular assist device such as impella, mechanical ventilation), left ventricular ejection fraction of \< 30% or comparable...
- Already accepted or currently on inhaled NO therapy or inhaled/aerosolized prostacyclin in the week prior to the enrollment;
- Endstage kidney disease with estimated glomerular filtration rate (eGFR) \< 15 ml/min or already on renal replacement surgery.
- Hemophilia A or B
- Other terminal stage of chronic disease with life expectancy less than 1 year per evaluation and adjudication of the attending physicians.
The study team makes the final eligibility decision.
Where it's taking place
- Boston, Massachusetts, United States
- Xi'an, Shaanxi, China
- Tomsk, Russia
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boston, Massachusetts, United States; Xi'an, Shaanxi, China; Tomsk, Russia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.