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New treatment option for Acute Respiratory Distress Syndrome (ARDS)
Official title Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.
ClinicalTrials.gov ID: NCT06694311
What this study is testing
- What it's testing
- The acute respiratory distress syndrome (ARDS) consists on a lack of breath due to fluid overload in the lungs that is not produced by a heart desease. Some people with this condition may need to be intubated and connected to invasive mechanical ventilation, but less severe cases may need supplementary oxygen that can be delivered with non-invasive devices, such as CPAP (continuous positive airway pressure) or HFNO (high flow nasal oxygenation).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- PaO2/FiO2 ratio \ 40% and PEEP ≥5 cmH2O (CPAP) or flow ≥30 L/min (HFNC).
- Bilateral pulmonary opacities observed in the chest X-ray, thoracic computerized tomography (CT) scan or lung ultrasonography (bilateral B lines)
- \<7 days from the pulmonary insult to symptom onset and criteria 1 and 2
- Not meeting the aforementioned criteria for \>24 hours prior to study inclusion.
You likely can't join if
- Age \ 80 years
- History of chronic respiratory failure or interstitial pulmonary disease
- Acute cardiogenic pulmonary edema after echocardiographic evaluation
- Having received either invasive mechanical ventilation or non-invasive mechanical ventilation (NIV)
- Atelectasis, pleural effusion, pulmonary masses or nodules as the primary finding in thoracic imaging.
- "Do not intubate, do not resuscitate" orders
See the full eligibility criteria
- PaO2/FiO2 ratio \ 40% and PEEP ≥5 cmH2O (CPAP) or flow ≥30 L/min (HFNC).
- Bilateral pulmonary opacities observed in the chest X-ray, thoracic computerized tomography (CT) scan or lung ultrasonography (bilateral B lines)
- \<7 days from the pulmonary insult to symptom onset and criteria 1 and 2
- Not meeting the aforementioned criteria for \>24 hours prior to study inclusion.
- Age \ 80 years
- History of chronic respiratory failure or interstitial pulmonary disease
- Acute cardiogenic pulmonary edema after echocardiographic evaluation
- Having received either invasive mechanical ventilation or non-invasive mechanical ventilation (NIV)
- Atelectasis, pleural effusion, pulmonary masses or nodules as the primary finding in thoracic imaging.
- "Do not intubate, do not resuscitate" orders
- Presenting significant nasal obstruction.
The study team makes the final eligibility decision.
Where it's taking place
- Barcelona, Barcelona, Spain
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Barcelona, Barcelona, Spain. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.