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Official title Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail Approach
ClinicalTrials.gov ID: NCT06693960
What this study is testing
What is Drug cocktail?
Drug cocktail is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for interaction.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this clinical trial is to determine how the supplement oregano affects how the body metabolizes pharmaceutical drugs.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 64. Healthy volunteers may be eligible.
You may be able to join if
- Between 18-64 years old and healthy
- Not taking any medications (prescription and non-prescription) or dietary/herbal supplements that can interfere with study drug pharmacokinetics
- Willing to abstain from consuming dietary/herbal supplements and citrus juices for several weeks
- Willing to abstain from cannabis/marijuana, hemp, and THC- and CBD-containing products for several weeks
- Willing to abstain from consuming caffeinated beverages or other caffeine-containing products the evening before and the morning of the first day of...
You likely can't join if
- Under 18 or over 64 years old
- Taking medications or dietary/herbal supplements that can interfere with study drug pharmacokinetics
- Have a major illness
- Taking medication/supplements for a mineral deficiency
- History of intolerance or allergy to oregano or any of the cocktail drugs (caffeine, dextromethorphan, losartan, midazolam, and omeprazole)
- Use of cannabis/marijuana, hemp, and CBD- and/or THC-containing products within the last month
See the full eligibility criteria
- Between 18-64 years old and healthy
- Not taking any medications (prescription and non-prescription) or dietary/herbal supplements that can interfere with study drug pharmacokinetics
- Willing to abstain from consuming dietary/herbal supplements and citrus juices for several weeks
- Willing to abstain from cannabis/marijuana, hemp, and THC- and CBD-containing products for several weeks
- Willing to abstain from consuming caffeinated beverages or other caffeine-containing products the evening before and the morning of the first day of each study arm
- Willing to abstain from consuming any alcoholic beverages for at least 1 day prior to any study day and during the study day
- Willing to use a secondary method of birth control that does not include the introduction or discontinuance of hormonal-based birth control (such as abstinence, copper IUD, or condoms). Specifically, regardless of the...
- Willing to abstain from consuming oregano (as a food additive or otherwise) for the duration of the study
- Geographically located within a 40-mile radius of Spokane and have the time to participate
- Under 18 or over 64 years old
- Taking medications or dietary/herbal supplements that can interfere with study drug pharmacokinetics
- Have a major illness
- Taking medication/supplements for a mineral deficiency
- History of intolerance or allergy to oregano or any of the cocktail drugs (caffeine, dextromethorphan, losartan, midazolam, and omeprazole)
- Use of cannabis/marijuana, hemp, and CBD- and/or THC-containing products within the last month
- Currently using drugs or illicit substances for recreational purposes
- Pregnant or nursing
- Geographically located outside the 40-mile radius of Spokane and do not have the time to participate
- Cannot read and speak English
The study team makes the final eligibility decision.
Where it's taking place
- Spokane, Washington, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 64 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Spokane, Washington, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.